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Immunosurgery of mouse blastocyst.
Open accessAbstract
Mouse blastocysts with and without zonae pellucidae are susceptible to complement-dependent antibody cytotoxicity. Exposure of blastocysts to rabbit anti-mouse serum together with complement results in the death of all cells; however, when blastocysts are exposed to antiserum alone and then transferred to guinea pig complement, only the trophoblastic cells are killed. These results suggest that the mouse blastocyst is not permeable for certain antibodies. The inner cell masses can easily be separated from the remnants of trophoblastic cells and are then able to grow and differentiate in vitro. This method of immunosurgery can be used to obtain large quantities of pure inner cell masses in a relatively short period of time.
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Cited by
Nichols, J., Zevnik, B., Anastassiadis, K., Niwa, H., Klewe-Nebenius, D., Chambers, I., Schöler, H., & Smith, A. (1998) · Cell · doi:10.1016/s0092-8674(00)81769-9 · Cited by 3,392
Multipotent cell lineages in early mouse development depend on SOX2 function
Avilion, A. A., Nicolis, S. K., Pevny, L. H., Perez, L., Vivian, N., & Lovell-Badge, R. (2003) · Genes & Development · doi:10.1101/gad.224503 · Cited by 2,369
Derivation of Embryonic Stem-Cell Lines from Human Blastocysts
Cowan, C. A., Klimanskaya, I., McMahon, J., Atienza, J., Witmyer, J., Zucker, J. P., Wang, S., Morton, C. C., McMahon, A. P., Powers, D., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmsr040330 · Cited by 964
Retrotransposons regulate host genes in mouse oocytes and preimplantation embryos
Peaston, A. E., Evsikov, A. V., Graber, J. H., de Vries, W. N., Holbrook, A. E., Solter, D., & Knowles, B. B. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.09.004 · Cited by 710
Self-citationDifferential Effects of Culture on Imprinted H19 Expression in the Preimplantation Mouse Embryo1
Doherty, A. S., Mann, M. R. W., Tremblay, K. D., Bartolomei, M. S., & Schultz, R. M. (2000) · Biology of Reproduction · doi:10.1095/biolreprod62.6.1526 · Cited by 722
Metadata
- Authors
- Solter, D., & Knowles, B. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1975-12
- Volume
- 72
- Issue
- 12
- Pages
- 5099-5102
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2048722178
- Cited by
- 664
- References
- 0
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Solter, D., & Knowles, B. B. (1975). Immunosurgery of mouse blastocyst. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.72.12.5099
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