The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2alpha in epidermis of psoriasis.
Open accessAbstract
Lesional epidermis of psoriasis has a probable reduction in the cyclic AMP/cyclic GMP ratio. This altered ratio may in part be responsible for the characteristic glycogen storage, rapid cell proliferation, and reduced differentiation in lesional epidermis. The concentrations of prostaglandins E2 and F2alpha, free arachidonic acid, and 12L-hydroxy-5,8,10,14-eicosatetrawnoic acid in specimens of uninvolved and involved epidermis of psoriasis were measured with deuterium-labeled carriers and multiple ion analysis. Snap frozen specimens contained: 1.4 +/- 0.4 mug/g (wet weight) of arachidonic acid in uninvolved in contrast to 36.3 +/- 16.7 mug/g in involved epidermis (P = 0.015); less than 0.05 +/- 0.01 mug/g of hydroxyeicosatetraenoic acid in uninvolved in contrast to 4.1 +/- 1.9 mug/g in involved epidermis (P = 0.015); 23.6 +/- 5.0 ng/g of prostaglandin E2 in uninvolved in contrast to 33.1 +/- 5.7 ng/g in involved epidermis (P less than 0.01); and 21.0 +/- 4.4 ng/g of prostaglandin F2alpha in uninvolved in contrast to 39.0 +/- 5.9 ng/g in involved epidermis (P less than 0.01). The arachidonic acid and hydroxyeicosatetraenoic acid levels in involved epidermis were strongly correlated (r = 0.97). The increased levels of arachidonic acid and 12L-hydroxy-5,8,10,14-eicosatetraenoic acid in involved epidermis may have diagnostic and pathophysiological importance.
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Cites
Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets
Hamberg, M., & Samuelsson, B. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.9.3400 · Cited by 1,407
Self-citationControl of proliferation in animal cells
Clarkson, B. D., & Baserga, R. (1974) · Cold Spring Harbor Laboratory eBooks · Cited by 1,196
Adenyl Cyclase in Normal and Transformed Fibroblasts in Tissue Culture
Peery, C. V., Johnson, G. S., & Pastan, I. H. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61873-3 · Cited by 123
Voorhees, J. J., Marcelo, C. L., & Duell, E. A. (1975) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12598125 · Cited by 87
Self-citationBiosynthesis and Metabolism of Prostaglandin E2in Human Skin
Jonsson, C. E., & Änggård, E. (1972) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517209080244 · Cited by 87
Aso, K., Deneau, D. G., Krulig, L., Wilkinson, D. I., & Farber, E. M. (1975) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12512267 · Cited by 38
Cited by
Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
Haeggström, J. Z., & Funk, C. D. (2011) · Chemical Reviews · doi:10.1021/cr200246d · Cited by 875
Lipids and the epidermal permeability barrier
Elias, P. M. (1981) · Archives of Dermatological Research · doi:10.1007/bf00417155 · Cited by 295
Fernandes, A., Rodrigues, P. M., Pintado, M., & Tavaria, F. K. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154824 · Cited by 264
Elias, P. M., Brown, B. E., & Ziboh, V. A. (1980) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12541775 · Cited by 257
Parenteral Nutrition with Fish Oil Modulates Cytokine Response in Patients with Sepsis
Mayer, K., Gokorsch, S., Fegbeutel, C., Hattar, K., Rosseau, S., Walmrath, D., Seeger, W., & Grimminger, F. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200207-674oc · Cited by 239
Metadata
- Authors
- Hammarström, S., Hamberg, M., Samuelsson, B., Duell, E. A., Stawiski, M., & Voorhees, J. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1975-12
- Volume
- 72
- Issue
- 12
- Pages
- 5130-5134
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2000976891
- Cited by
- 586
- References
- 6
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2alpha in epidermis of psoriasis. https://app.cochat.ai/papers/10.1073/pnas.72.12.5130
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- Hammarström, S., Hamberg, M., Samuelsson, B., Duell, E. A., Stawiski, M., & Voorhees, J. J. (1975). Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2alpha in epidermis of psoriasis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.72.12.5130
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
