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Human epidermal growth factor: isolation and chemical and biological properties.
Open accessAbstract
A polypeptide hormone has been isolated from human urine, human epidermal growth factor. It was assayed by its ability to compete with 125I-labeled mouse-derived epidermal growth factor in binding to human foreskin fibroblasts. The biological effects of the human polypeptide are similar to those previously described for the mouse hormone. These include the stimulation of the growth in vitro of human foreskin fibroblasts and corneal epithelial cells in organ culture, and the in vivo induction of precocious eyelid opening in the newborn mouse. The amino acid compositions of the two polypeptides differ, although certain similarities are present. The estimated molecular weight of the human polypeptide, 5300-5500, is slightly lower than that of the mouse hormone. Both polypeptides apparently compete for the same site on the cell membrane; and antibodies to the mouse polypeptide crossreact to some extent with the human hormone.
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Cited by
Untangling the ErbB signalling network
Yarden, Y., & Sliwkowski, M. X. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052073 · Cited by 6,974
Growth factors: Mechanism of action and relation to oncogenes
Heldin, C.-H., & Westermark, B. (1984) · Cell · doi:10.1016/0092-8674(84)90296-4 · Cited by 854
Wright, N. A., Pike, C., & Elia, G. (1990) · Nature · doi:10.1038/343082a0 · Cited by 462
Gorden, P., Carpentier, J. L., Cohen, S., & Orci, L. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.10.5025 · Cited by 351
Self-citationBiology of Interactions: Antiepidermal Growth Factor Receptor Agents
Harari, P. M., Allen, G. W., & Bonner, J. A. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.11.8984 · Cited by 214
Metadata
- Authors
- Cohen, S., & Carpenter, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1975-04
- Volume
- 72
- Issue
- 4
- Pages
- 1317-1321
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1998599114
- Cited by
- 509
- References
- 0
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- green
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