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NAD-dependent inhibition of protein synthesis by Pseudomonas aeruginosa toxin,.
Open accessAbstract
Pseudomonas aeruginosa toxin (PA toxin) inhibits protein synthesis in a reticulocyte cell-free system. The inhibition requires NAD and results in a block at an elongation step of polypeptide assembly. PA toxin was found to act like diphtheria toxin fragment A. Both toxins catalyze the transfer of radioactivity from nicotinamide(U-14-C)adenine dinucleotide ((14-C)NAD) into covalent linkage with the 100,000 dalton elongation (EF-2) protein. Furthermore, in the presence of a limiting amount of EF-2, excess toxin, and (14-C)NAD, the two toxins were non-additive in the amount of label transferred to EF-3. Unlike free fragment A of diphtheria toxin, the enzymatic activity of PA toxin is heat labile and neutralizable with antibody to PA toxin but not with antibody to fragment A. Although PA and diphtheria toxins have different cellular specificities and molecular properties and produce different clinical symptoms, their intracellular mechanisms of action appear to be identical.
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Citations
Cited by
Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes.
Pearson, J. P., Gray, K. M., Passador, L., Tucker, K. D., Eberhard, A., Iglewski, B. H., & Greenberg, E. P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.197 · Cited by 990
Self-citationPoly (ADP-Ribose) and ADP-Ribosylation of Proteins
Hayaishi, O., & Veda, K. (1977) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.46.070177.000523 · Cited by 585
Kounnas, M. Z., Morris, R. E., Thompson, M. R., FitzGerald, D. J., Strickland, D. K., & Saelinger, C. B. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42291-0 · Cited by 447
Gambello, M. J., Kaye, S., & Iglewski, B. H. (1993) · Infection and Immunity · doi:10.1128/iai.61.4.1180-1184.1993 · Cited by 379
Self-citationThe response of Pseudomonas aeruginosa to iron: genetics, biochemistry and virulence
Vasil, M. L., & Ochsner, U. A. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01586.x · Cited by 366
Metadata
- Authors
- Iglewski, B. H., & Kabat, D.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1975-06
- Volume
- 72
- Issue
- 6
- Pages
- 2284-2288
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2014335282
- Cited by
- 620
- References
- 0
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Iglewski, B. H., & Kabat, D. (1975). NAD-dependent inhibition of protein synthesis by Pseudomonas aeruginosa toxin,. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.72.6.2284
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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