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Substrate specificity of the cyclic AMP-dependent protein kinase.
Open accessAbstract
The protein substrate specificity of the catalytic subunit of rabbit skeletal muscle cyclic AMP-dependent protein kinase (EC 2.7.1.37; ATP:protein phosphotransferase) has been studied using genetic variants of beta casein. It was found that beta casein-B was phosphorylated at a much greater rate than beta caseins A1, A2, A3, or C. The enhanced phosphorylation of beta casein-B, as compared with the most common variant A2, was attributed to an arginine substitution for a serine at position 122, which caused a nearby residue, serine 124, to become a phosphorylation site for the protein kinase. These results further support the concept that the local primary structure is important in specificity and that arginine may be a specific determinant common to all the local phosphorylation site sequences recognized by the cyclic AMP-dependent protein kinase.
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Citations
Cited by
Mechanisms of specificity in protein phosphorylation
Ubersax, J. A., & Ferrell Jr, J. E. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2203 · Cited by 1,451
Kemp, B. E., Graves, D. J., Benjamini, E., & Krebs, E. G. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40137-2 · Cited by 835
Self-citationSignalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions
BIONDI, R. M., & NEBREDA, A. R. (2003) · Biochemical Journal · doi:10.1042/bj20021641 · Cited by 334
Szmigielski, A., Guidotti, A., & Costa, E. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40329-2 · Cited by 92
Metadata
- Authors
- Kemp, B. E., Bylund, D. B., Huang, T. S., & Krebs, E. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1975-09
- Volume
- 72
- Issue
- 9
- Pages
- 3448-3452
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2030349770
- Cited by
- 198
- References
- 0
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- green
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- Kemp, B. E., Bylund, D. B., Huang, T. S., & Krebs, E. G. (1975). Substrate specificity of the cyclic AMP-dependent protein kinase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.72.9.3448
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