The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
An effect of castration and testosterone replacement on a circadian pacemaker in mice (Mus musculus).
Open accessAbstract
Castration of mice in freerunning conditions (total darkness, DD) causes a reduction of running wheel activity in the beginning of the active period (alpha) and stimulates activity at the end of alpha. Simultaneously, the period (tau) of the freerunning rhythm is increased. Both effects are abolished by implantation of a Silastic capsule from which a physiological dose of testosterone is released at a constant rate. The results are tentatively explained by differential endocrine influences on two oscillating components in the pacemaker of the circadian activity rhythm.
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“Indeed, in adult laboratory rodents a wide variety of gonadal hormones can affect the phase of circadian rhythms, including estrogens, progestins, androgens, and non-traditional neuroactive steroids (e.g., rats: [8, 17], hamsters: [49, 51, 129], mice: [23, 47, 78, 90], degus: [80, 100]).”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [47]
In the citing paper
“Gonadal hormones can influence other circadian parameters as well, including endogenous period [7, 23, 47, 49, 91, 129, 212], rhythm amplitude [8, 17, 100], range of entrainment [49], zeitgeber sensitivity [23, 51, 79, 81], and oscillator coupling [126, 128, 187].”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [47]
In the citing paper
“For example, castrated adult male rodents under entrained and free-running conditions had activity that was more dispersed across the active period [128], such that activity at the beginning of their active period in the early night was less cohesive, diminished, lost, or delayed [47, 49, 78, 90, 128, although see 23 and 80].”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [47]
In the citing paper
“In these previous studies, the administration of testosterone or dihydrotestosterone to castrated adult males was able to restore the normal circadian activity patterns [47, 78, 90, 128] and estrogen treatment was able to reconsolidate rhythms in ovariectomized rats [187, 203].”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [47]
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Citations
Cites
A retinohypothalamic projection in the rat
Moore, R. Y., & Lenn, N. J. (1972) · The Journal of Comparative Neurology · doi:10.1002/cne.901460102 · Cited by 1,263
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Richter, C. P. (1927) · The Quarterly Review of Biology · doi:10.1086/394279 · Cited by 474
Biological Rhythms and Animal Behavior
Rusak, B., & Zucker, I. (1975) · Annual Review of Psychology · doi:10.1146/annurev.ps.26.020175.001033 · Cited by 219
Sustained release hormonal preparations. I. Diffusion of various steroids through polymer membranes
Kinel, F. A., Benagiano, G., & Angee, I. (1968) · Steroids · doi:10.1016/s0039-128x(68)80013-3 · Cited by 140
Testosterone Induces "Splitting" of Circadian Locomotor Activity Rhythms in Birds
Gwinner, F. (1974) · Science · doi:10.1126/science.185.4145.72 · Cited by 139
Circadian rhythms in adrenal organ cultures.
Rv, A. (1971) · PubMed · Cited by 48
Persistence of Diurnal Periodicity of CRF Activity in Adrenalectomized and Hypophysectomized Rats
Takebe, K., Sakakura, M., Horiuchi, Y., & Mashimo, K. (1971) · Endocrinologia Japonica · doi:10.1507/endocrj1954.18.451 · Cited by 5
Research works printed but not linked: 7
- [3]Menaker, M. (1974). "Aspects of the physiology of circadian rhythmicity in the vertebrate central nervous system," in The Neurosciences, IIIrd Study Program, eds. Schmitt, F. O. & Worden, G. O. (MIT Press, Cambridge, Mass.), pp. 479–489. 4.
- [8]Pittendrigh, C. S. & Daan, S. (1975) "A functional analysis of circadian pacemakers in nocturnal rodents. I. The stability and lability of spontaneous frequency," J. Comp. Physiol., in press.
- [13]Daan, S. & Pittendrigh, C. S. (1975) "A functional analysis of circadian pacemakers in nocturnal rodents. III. Heavy water and constant light: homeostasis of frequency?," J. Comp. Physiol., in press.
- [15]Pittendrigh, C. S. & Daan, S. (1975) "A functional analysis of circadian pacemakers in nocturnal rodents. V. Pacemaker complexity: A clock for all seasons," J. Comp. Physiol., in press.
- [14]Pittendrigh, C. S. (1974) "Circadian oscillations in cells and the circadian organization of multi-cellular systems,"in The Neurosciences, Third Study Program, eds. (Schmitt, F. O. & Worden, G. O. (MIT Press, Cambridge Mass.), pp. 437–458.
- [16]Gwinner, E. (1975) "Effects of season and external testosterone on the freerunning circadian activity rhythms of European starlings," J. Comp. Physiol., in press.
- [17]Daan, S. (1975) "Light intensity and the timing of daily activity in finches,"The Ibis, in press.
Cited by
Sorted by citations
A functional analysis of circadian pacemakers in nocturnal rodents
Pittendrigh, C. S., & Daan, S. (1976) · Journal of Comparative Physiology A · doi:10.1007/bf01417856 · Cited by 2,129
Pittendrigh, C. S., & Daan, S. (1976) · Journal of Comparative Physiology ? A · doi:10.1007/bf01417860 · Cited by 1,636
Inouye, S. T., & Kawamura, H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.11.5962 · Cited by 985
Sex difference in the near-24-hour intrinsic period of the human circadian timing system
Duffy, J. F., Cain, S. W., Chang, A., Phillips, A. J. K., Münch, M. Y., Gronfier, C., Wyatt, J. K., Dijk, D., Wright, K. P., & Czeisler, C. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010666108 · Cited by 601
Aschoff, J. (2010) · Zeitschrift für Tierpsychologie · doi:10.1111/j.1439-0310.1979.tb00290.x · Cited by 475
Metadata
- Authors
- Daan, S., Damassa, D., Pittendrigh, C. S., & Smith, E. R.
- Affiliations
- Stanford University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1975-09
- Volume
- 72
- Issue
- 9
- Pages
- 3744-3747
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC433074
- OpenAlex
- W2146972815
- Cited by
- 207
- References
- 7
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 7 · 2013: 7 · 2012: 8
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- castration, testosterone replacement therapy, circadian pacemaker, circadian activity rhythm, wheel running, period length, mice
- MeSH terms
- Animals, Behavior, Animal, Castration, Circadian Rhythm, Drug Implants, Male, Mice, Inbred C57BL, Motor Activity, Testosterone, Mice
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