Persistence of circadian rhythmicity in a mammalian hypothalamic “island” containing the suprachiasmatic nucleus
Open accessAbstract
The experimental work described tested the prosposition that the suprachiasmatic nucleus of the hypothalamus is an autonomous circadian pacemaker. Simultaneous recording from two extracellular electrodes indicated neural (multiple unit) activity at two sites in the brain, one of which is in or near the suprachiasmatic nucleus and the other in one of many other brain locations. Both sites in intact rats displayed clear circadian rhythmicity of spontaneous neural activity. In experimental animals, a Halasz knife was used to create an island of hypothalamic tissue that contained the suprachiasmatic nuclei. In such animals that were also blinded by bilateral ocular enucleation, circadian rhythmicity was lost at all brain locations recorded outside the island, but it persisted within the island that contained the suprachiasmatic nuclei. The rhythmicity of the island is thus not dependent on afferent inputs from elsewhere in the brain.
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The suprachiasmatic nuclei express a robust circadian rhythm of electrophysiologic activity even when isolated from the rest of the brain.
“The SCN express a robust circadian rhythm of electrophysiologic activity, even when isolated from the rest of the brain (3,4).”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [3]
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- Authors
- Inouye, S. T., & Kawamura, H.
- ORCID
- Kawamura, H
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1979-11
- Volume
- 76
- Issue
- 11
- Pages
- 5962-5966
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC411773
- OpenAlex
- W2020551161
- Cited by
- 985
- References
- 21
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 16 · 2023: 23 · 2022: 23 · 2021: 29 · 2020: 28 · 2019: 14 · 2018: 21 · 2017: 22 · 2016: 17 · 2015: 22 · 2014: 31 · 2013: 25 · 2012: 21
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- suprachiasmatic nucleus, circadian pacemaker, circadian rhythmicity, multi-unit activity, ocular enucleation, bilateral enucleation, rats
- MeSH terms
- Action Potentials, Animals, Biological Clocks, Blindness, Caudate Nucleus, Circadian Rhythm, Hypothalamus, Male, Substantia Nigra, Supraoptic Nucleus, Rats
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