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Opiate receptor: autoradiographic localization in rat brain.
Open accessAbstract
Opiate receptor sites in rat brain can be labeled in vivo by [3H]diprenorphine, a potent opiate antagoinst. Using techniques to minimize diffusion in fresh, frozen, unfixed brain, we have localized [3H]diprenorphine by autoradiography to visualize the distribution of opiate receptors. Silver grains indicative of the binding of labeled [3H]diprenorphine are discretely localized in numerous areas of the brain with very high densities in the locus coeruleus, the substantia gelatinosa of the spinal cord, and in clusters within the caudate-putamen, amygdala, and parts of the periventricular gray matter.
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Cites
Identification of two related pentapeptides from the brain with potent opiate agonist activity
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806
Rat brain binds adrenal steroid hormone: Radioautography of hippocampus with corticosterone
Gerlach, J. L., & McEwen, B. S. (1972) · Science · doi:10.1126/science.175.4026.1133 · Cited by 306
Cited by
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Herkenham, M., & Nauta, W. J. H. (1979) · Journal of Comparative Neurology · doi:10.1002/cne.901870103 · Cited by 853
Gerfen, C. R. (1984) · Nature · doi:10.1038/311461a0 · Cited by 837
Graybiel, A. M., & Ragsdale, C. W. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.11.5723 · Cited by 784
Gerfen, C., Herkenham, M., & Thibault, J. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-12-03915.1987 · Cited by 803
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Salgado, S., & Kaplitt, M. G. (2015) · Stereotactic and Functional Neurosurgery · doi:10.1159/000368279 · Cited by 489
Metadata
- Authors
- Pert, C. B., Kuhar, M. J., & Snyder, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-10
- Volume
- 73
- Issue
- 10
- Pages
- 3729-3733
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1987880564
- Cited by
- 629
- References
- 2
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Pert, C. B., Kuhar, M. J., & Snyder, S. H. (1976). Opiate receptor: autoradiographic localization in rat brain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.10.3729
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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