The nucleus accumbens: a comprehensive review
Abstract
There is increasing interest among functional neurosurgeons in the potential for novel therapies to impact upon diseases beyond movement disorders and pain. A target of increasing interest is the nucleus accumbens (NAc), which has long been studied as a key brain region mediating a variety of behaviors, including reward and satisfaction. As such, focal modulation of the biology of the NAc with deep brain stimulation or novel biological therapies such as gene therapy or cell transplantation could have a major impact upon disorders such as depression and drug addiction. In order to both develop appropriate therapies and then deliver them in an effective fashion, a thorough understanding of the biology, physiology, and anatomy of the NAc is critical. Here, we review the existing literature regarding several areas critical to the development of new therapies, including the known pharmacology, physiology, and connectivity of the NAc, as well as evidence supporting the potential for various NAc surgical therapies in animal models. We then review the relevant anatomy of the NAc, with particular attention to the surgical anatomy, imaging, and targeting necessary to facilitate a proper localization and delivery of new agents to this region. The NAc is a fascinating and potentially rich target for stereotactic neurosurgical intervention, and analysis of existing information regarding all aspects of this structure should help potentiate therapeutic advances and reduce complications from future studies of neurosurgical intervention in this region for a variety of disorders. © 2015 S. Karger AG, Basel.
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VC/VS targets structurally and functionally connect to the MFB and partially to the SCC, but the SCC has selective fibers not directly connected to VC/VS or NAc.
“DBS targets in the VC/VS region structurally and functionally connect to the MFB and partially to the SCC [91], but the SCC has selective fibers that are not directly connected to VC/VS or NAc [92,93].”
From Deep brain stimulation for depression. (2022) · cites this paper as [91]
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- Authors
- Salgado, S., & Kaplitt, M. G.
- Affiliations
- Weill Cornell Medicine (US)
- Corresponding author
- Salgado, Sanjay
- Venue
- Stereotactic and Functional Neurosurgery
- Publisher
- S. Karger AG
- Published
- 2015
- Volume
- 93
- Issue
- 2
- Pages
- 75-93
- ISSN
- 1011-6125 (ISSN-L)
- 1423-0372
- OpenAlex
- W4292687491
- Cited by
- 489
- References
- 304
- Citations by year
- 2026: 33 · 2025: 51 · 2024: 62 · 2023: 80 · 2022: 55 · 2021: 58 · 2020: 45 · 2019: 33 · 2018: 24 · 2017: 29 · 2016: 11 · 2015: 7
- FWCI
- 16.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stereotactic and Functional Neurosurgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Keywords
- nucleus accumbens, deep brain stimulation, gene therapy, cell transplantation, depression, drug addiction, reward, stereotactic neurosurgery, surgical anatomy, neuroimaging, neuronal connectivity, animal models
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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