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DNA gyrase: an enzyme that introduces superhelical turns into DNA.
Open accessAbstract
Relaxed closed-circular DNA is converted to negatively supercoiled DNA by DNA gyrase. This enzyme has been purified from Escherichia coli cells. The reaction requires ATP and Mg++ and is stimulated by spermidine. The enzyme acts equally well on relaxed closed-circular colicin E1, phage lambda, and simian virus 40 DNA. The final superhelix density of the DNA can be considerably greater than that found in intracellularly supercoiled DNA.
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Citations
Cited by
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology
Schoeffler, A. J., & Berger, J. M. (2008) · Quarterly Reviews of Biophysics · doi:10.1017/s003358350800468x · Cited by 490
Topoisomerases as anticancer targets
Delgado, J. L., Hsieh, C.-M., Chan, N.-L., & Hiasa, H. (2018) · Biochemical Journal · doi:10.1042/bcj20160583 · Cited by 481
Addiction Modules and Programmed Cell Death and Antideath in Bacterial Cultures
Engelberg-Kulka, H., & Glaser, G. (1999) · Annual Review of Microbiology · doi:10.1146/annurev.micro.53.1.43 · Cited by 361
Reverse gyrase—a topoisomerase which introduces positive superhelical turns into DNA
Kikuchi, A., & Asai, K. (1984) · Nature · doi:10.1038/309677a0 · Cited by 292
ParE toxin encoded by the broad‐host‐range plasmid RK2 is an inhibitor of Escherichia coli gyrase
Jiang, Y., Pogliano, J., Helinski, D. R., & Konieczny, I. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02921.x · Cited by 273
Metadata
- Authors
- Gellert, M., Mizuuchi, K., O'Dea, M. H., & Nash, H. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-11
- Volume
- 73
- Issue
- 11
- Pages
- 3872-3876
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1979700870
- Cited by
- 1,204
- References
- 0
- FWCI
- 24.77
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: DNA gyrase: an enzyme that introduces superhelical turns into DNA. https://app.cochat.ai/papers/10.1073/pnas.73.11.3872
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- Gellert, M., Mizuuchi, K., O'Dea, M. H., & Nash, H. A. (1976). DNA gyrase: an enzyme that introduces superhelical turns into DNA. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.11.3872
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
