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Opiate and stimulus-produced analgesia: functional anatomy of a medullospinal pathway.
Open accessAbstract
Neurons in ventromedial medulla, including the nucleus raphe magnus, project to trigeminal nucleus caudalis and, via the dorsolateral funiculus, to spinal dorsal horn. The terminals of this descending system are in loci containing cells responsive to noxious stimuli. Electrical stimulation of nucleus raphe magnus selectively inhibits spinal dorsal horn neurons that respond to noxious stimuli. These neurons are located near the anatomically demonstrated terminals of this descending system. Dorsolateral funiculus lesions block this descending inhibition of spinal neurons as well as the analgesic action of morphine. This evidence supports the hypothesis that this neuron population mediates the analgesia produced by opiates and electrical stimulation of certain diencephalic and brainstem sites.
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Cited by
Neuroanatomy of the pain system and of the pathways that modulate pain
Willis, W. D., & Westlund, K. N. (1997) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199701000-00002 · Cited by 924
Anatomy of the Descending Pathways
Kuypers, H. G. J. M. (1981) · Comprehensive Physiology · doi:10.1002/cphy.cp010213 · Cited by 640
Sakai, K., Sastre, J. P., Salvert, D., Touret, M., Tohyama, M., & Jouvet, M. (1979) · Brain Research · doi:10.1016/0006-8993(79)90981-8 · Cited by 337
Katayama, Y., DeWitt, D. S., Becker, D. P., & Hayes, R. L. (1984) · Brain Research · doi:10.1016/0006-8993(84)90062-3 · Cited by 296
The organization and function of endogenous antinociceptive systems
Sandkühler, J. (1996) · Progress in Neurobiology · doi:10.1016/0301-0082(96)00031-7 · Cited by 255
Metadata
- Authors
- Basbaum, A. I., Clanton, C. H., & Fields, H. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-12
- Volume
- 73
- Issue
- 12
- Pages
- 4685-4688
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2039457981
- Cited by
- 294
- References
- 0
- FWCI
- 20.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Basbaum, A. I., Clanton, C. H., & Fields, H. L. (1976). Opiate and stimulus-produced analgesia: functional anatomy of a medullospinal pathway. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.12.4685
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