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Escherichia coli thioredoxin: a subunit of bacteriophage T7 DNA polymerase.
Open accessAbstract
T7 DNA polymerase (DNA nucleotidyltransferase; deoxynucleosidetriphosphate:DNA deoxynucleotidyltransferase, EC 2.7.7.7) is composed of an 84,000 dalton protein specified by the gene 5 of the phage and a 12,000 dalton protein (TsnC protein) specified by the tsnC gene of E. coli [Modrich, P. & Richardson, C. C. (1975) J. Biol. Chem. 250 5515-5522]. Both proteins are necessary for T7 DNA polymerase activity and for the replication of T7 DNA. The TsnC protein is identical to thioredoxin of E. coli by the following criteria: (1) Homogeneous preparations of both proteins have TsnC and thioredoxin activity. (2) Both proteins show similar stability to heat. (3) They have identical mobilities, corresponding to a molecular weight of 12,000, on polyacrylamide gels containing sodium dodecyl sulfate. (4) Their amino-acid compositions are indistinguishabe. (5) Antibody prepared against thioredoxin inhibits TsnC activity. (6) TsnC protein isolated from purified T7 DNA polymerase has thioredoxin activity. In addition, preparations of T7 DNA polymerase itself exhibit thioredoxin activity and are partially inhibited by antibody to thioredoxin.
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Cited by
Jeffery, C. J. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01335-8 · Cited by 1,016
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Bachmann, B., & Low, K. B. (1980) · Microbiological Reviews · doi:10.1128/mmbr.44.1.1-56.1980 · Cited by 938
Thioredoxin and Related Molecules–From Biology to Health and Disease
Lillig, C. H., & Holmgren, A. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.9.25 · Cited by 724
Moonlighting proteins: an intriguing mode of multitasking
Huberts, D. H. E. W., & van der Klei, I. J. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.01.022 · Cited by 405
Thioredoxin and glutathione regulate photosynthesis in chloroplasts
WOLOSIUK, R. A., & BUCHANAN, B. B. (1977) · Nature · doi:10.1038/266565a0 · Cited by 344
Metadata
- Authors
- Mark, D. F., & Richardson, C. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-03
- Volume
- 73
- Issue
- 3
- Pages
- 780-784
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2080569016
- Cited by
- 272
- References
- 0
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- green
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