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Moonlighting proteins
Abstract
The idea of one gene--one protein--one function has become too simple because increasing numbers of proteins are found to have two or more different functions. The multiple functions of such moonlighting proteins add another dimension to cellular complexity and benefit cells in several ways. However, cells have had to develop sophisticated mechanisms for switching between the distinct functions of these proteins.
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“Such multifunctionality has been increasingly recognized in bacteria, where metabolic enzymes, structural proteins, and transporters adopt additional roles beyond their canonical functions (31, 32).”
From Adaptive evolution of Pseudomonas putida in the presence of fluoride exposes novel functions of a benzoate transporter (2026) · cites this paper as [32]
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Research works printed but not linked: 28
- Ostrovsky de Spicer, 1993, Proc. Natl. Acad. Sci. U. S. A., 90, 4295, 10.1073/pnas.90.9.4295 · DOI
- Muro-Pastor, 1997, J. Bacteriol., 179, 2788, 10.1128/jb.179.8.2788-2791.1997 · DOI
- Chaput, 1988, Nature, 332, 454, 10.1038/332454a0 · DOI
- Faik, 1988, Nature, 332, 455, 10.1038/332455a0 · DOI
- Gurney, 1986, Science, 234, 574, 10.1126/science.3020690 · DOI · Paper page
- Gurney, 1986, Science, 234, 566, 10.1126/science.3764429 · DOI · Paper page
- Watanabe, 1996, Cancer Res., 56, 2960
- Xu, 1996, Blood, 87, 4502, 10.1182/blood.V87.11.4502.bloodjournal87114502 · DOI
- Furukawa, 1992, Nature, 356, 668, 10.1038/356668a0 · DOI
- Soker, 1998, Cell, 92, 735, 10.1016/S0092-8674(00)81402-6 · DOI
- Meyer-Siegler, 1991, Proc. Natl. Acad. Sci. U. S. A., 88, 8460, 10.1073/pnas.88.19.8460 · DOI
- Kennedy, 1992, Proc. Natl. Acad. Sci. U. S. A., 89, 11730, 10.1073/pnas.89.24.11730 · DOI
- Wolff, 1988, J. Bacteriol., 170, 4509, 10.1128/jb.170.10.4509-4515.1988 · DOI
- Mowbray, 1990, J. Biol. Chem., 265, 15638, 10.1016/S0021-9258(18)55445-4 · DOI
- Basilion, 1994, Proc. Natl. Acad. Sci. U. S. A., 91, 574, 10.1073/pnas.91.2.574 · DOI
- Citron, 1992, Proc. Natl. Acad. Sci. U. S. A., 89, 11891, 10.1073/pnas.89.24.11891 · DOI
- Mark, 1976, Proc. Natl. Acad. Sci. U. S. A., 73, 780, 10.1073/pnas.73.3.780 · DOI
- Stutts, 1995, Science, 269, 847, 10.1126/science.7543698 · DOI
- Hardy, 1995, EMBO J., 14, 68, 10.1002/j.1460-2075.1995.tb06976.x · DOI
- Luckie, 1994, Am. J. Physiol., 267, C650, 10.1152/ajpcell.1994.267.2.C650 · DOI
- Vu, 1991, Cell, 64, 1057, 10.1016/0092-8674(91)90261-V · DOI
- Chu, 1991, Proc. Natl Acad. Sci. U. S. A., 88, 8977, 10.1073/pnas.88.20.8977 · DOI
- Barker, 1981, J. Mol. Biol., 146, 469, 10.1016/0022-2836(81)90043-7 · DOI
- Cascalho, 1998, Science, 279, 1207, 10.1126/science.279.5354.1207 · DOI
- Wool, 1996, Trends Biochem. Sci., 21, 164, 10.1016/0968-0004(96)20011-8 · DOI
- Piatigorsky, 1998, Ann. New York Acad. Sci., 842, 7, 10.1111/j.1749-6632.1998.tb09626.x · DOI
- Suzuki, 1997, Trends Biochem. Sci., 22, 118, 10.1016/S0968-0004(97)01020-7 · DOI
- Low, 1993, J. Biol. Chem., 268, 14627, 10.1016/S0021-9258(18)82379-1 · DOI
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Metadata
- Authors
- Jeffery, C. J.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 24
- Issue
- 1
- Pages
- 8-11
- ISSN
- 0968-0004
- Cited by
- 1,016
- References
- 0
- Language
- en
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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