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Sequence-specific recognition of double helical nucleic acids by proteins.
Open accessAbstract
The base pairs in double helical nucleic acids have been compared to see how they can be recognized by proteins. We conclude that a single hydrogen bond is inadequate for uniquely identifying any particular base pair, as this leads to numerous degeneracies. However, using two hydrogen bonds, fidelity of base pair recognition may be achieved. We propose specific amino-acid side chain interactions involving two hydrogen bonds as a component of the recognition system for base pairs. In the major groove we suggest that asparagine or glutamine binds to adenine of the base pair or arginine binds to guanine. In the minor groove, we suggest an interaction between asparagine or glutamine with guanine of the base pair. We also discuss the role that ions and other amino-acid side chains may play in recognition interactions.
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Cited by
Recognition of Cognate Transfer RNA by the 30 S Ribosomal Subunit
Ogle, J. M., Brodersen, D. E., Clemons, W. M., Tarry, M. J., Carter, A. P., & Ramakrishnan, V. (2001) · Science · doi:10.1126/science.1060612 · Cited by 1,162
The role of DNA shape in protein–DNA recognition
Rohs, R., West, S. M., Sosinsky, A., Liu, P., Mann, R. S., & Honig, B. (2009) · Nature · doi:10.1038/nature08473 · Cited by 1,096
Kunkel, T. A., & Bebenek, K. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.497 · Cited by 1,003
Luscombe, N. M. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.13.2860 · Cited by 981
Ellenberger, T. E., Brandl, C. J., Struhl, K., & Harrison, S. C. (1992) · Cell · doi:10.1016/s0092-8674(05)80070-4 · Cited by 972
Metadata
- Authors
- Seeman, N. C., Rosenberg, J. M., & Rich, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-03
- Volume
- 73
- Issue
- 3
- Pages
- 804-808
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1986586522
- Cited by
- 1,125
- References
- 0
- FWCI
- 8.30
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Sequence-specific recognition of double helical nucleic acids by proteins. https://app.cochat.ai/papers/10.1073/pnas.73.3.804
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- Seeman, N. C., Rosenberg, J. M., & Rich, A. (1976). Sequence-specific recognition of double helical nucleic acids by proteins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.3.804
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