The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Biological consequences of incorporation of 5-fluorocytidine in the RNA of 5-fluorouracil-treated eukaryotic cells
Open accessAbstract
Treatment of HeLa cells with 5-fluoro-[3H]uracil leads to the incorporation into cellular RNA of 5-fluorocytidine to the extent of about 0.2% of the 5-fluorouridine incorporated. In tobacco mosaic virus RNA produced in tobacco leaves this ratio is one order of magnitude lower. Copolymers of cytidylic with 5-fluorocytidylic acids show unchanged template activity with E. coli RNA polymerase, but slightly altered messenger activity in the wheat germ system, compared to poly(C), and it is suggested that some of the biological consequences of 5-fluorouracil treatment of living cells and organisms may be attributed to this mechanism.
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Cites
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PLAQUE FORMATION AND ISOLATION OF PURE LINES WITH POLIOMYELITIS VIRUSES
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Studies on the incorporation of 5-fluorouracil into a virus nucleic acid
Gordon, M. P., & STAEHELIN, M. (1959) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(59)90177-5 · Cited by 75
Relationship between the mutagenic and base-stacking properties of halogenated uracil derivatives
Sternglanz, H., & Bugg, C. E. (1975) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(75)90130-6 · Cited by 71
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Self-citationPolynucleotide analogues II. Stimulation of amino acid incorporation by polynucleotide analogues
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Cited by
Insight into the Mechanisms and Clinical Relevance of Antifungal Heteroresistance
Su, Y., Li, Y., Yi, Q., Xu, Y., Sun, T., & Li, Y. (2025) · Journal of Fungi · doi:10.3390/jof11020143 · Cited by 18
Metadata
- Authors
- Gleason, M. K., & Fraenkel-Conrat, H.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1976-05
- Volume
- 73
- Issue
- 5
- Pages
- 1528-1531
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC430330
- OpenAlex
- W2024860647
- Cited by
- 29
- References
- 21
- Citations by year
- 2025: 1 · 2018: 1 · 2016: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- 5-fluorouracil, RNA incorporation, HeLa cells, tobacco mosaic virus RNA, antitumor drug mechanism
- MeSH terms
- Cytosine, Flucytosine, Fluorouracil, HeLa Cells, Mutation, RNA, Messenger, RNA, Viral, Structure-Activity Relationship, Templates, Genetic, Tobacco Mosaic Virus
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- This page
- CoChat. (2026). Citation check: Biological consequences of incorporation of 5-fluorocytidine in the RNA of 5-fluorouracil-treated eukaryotic cells. https://app.cochat.ai/papers/10.1073/pnas.73.5.1528
- The paper
- Gleason, M. K., & Fraenkel-Conrat, H. (1976). Biological consequences of incorporation of 5-fluorocytidine in the RNA of 5-fluorouracil-treated eukaryotic cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.5.1528
