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Changes in type of collagen synthesized as clones of chick chondrocytes grow and eventually lose division capacity.
Open accessAbstract
Clones of embryonic chick chondrocytes have been isolated and collagen biosynthesis has been followed as the clones grow and eventually lose division capacity. Analysis of collagen type at each successive subculture until the time of cellular senescence has shown that a change in synthesis occurs from the cartilage-specific Type II collagen (chain composition [alpha1(II)]3) to a mixture of Type I collagen (chain composition [alpha1(I)2alpha2) and the Type I trimer (chain composition[alpha1(I)]3). The results demonstrate unequivocally that the expression of the chick chondrocyte phenotype is unstable in vitro, and that previous experiments with mass cultures of chondrocytes cannot be accounted for by overgrowth of fibroblasts. Since similar morphological changes and a similar "switching" in collagen biosynthesis have been observed after growth of chondrocytes for a few days in 5-bromo-2'-deoxyuridine, it is proposed that growth in this analog accelerates those changes that eventually lead to cellular senescence.
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Cited by
Benya, P. D., & Shaffer, J. D. (1982) · Cell · doi:10.1016/0092-8674(82)90027-7 · Cited by 2,284
Benoit, D. S. W., Schwartz, M. P., Durney, A. R., & Anseth, K. S. (2008) · Nature Materials · doi:10.1038/nmat2269 · Cited by 825
The Biosynthesis of Collagen and Its Disorders
Prockop, D. J., Kivirikko, K. I., Tuderman, L., & Guzman, N. A. (1979) · New England Journal of Medicine · doi:10.1056/nejm197907123010204 · Cited by 574
Chemical, biochemical, functional, and nutritional characteristics of collagen in food systems
Asghar, A., & Henrickson, R. L. (1982) · Advances in Food Research · doi:10.1016/s0065-2628(08)60113-5 · Cited by 203
De novo neo-hyaline-cartilage from bovine organoids in viscoelastic hydrogels
Crispim, J. F., & Ito, K. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.04.008 · Cited by 71
Metadata
- Authors
- Mayne, R., Vail, M. S., Mayne, P. M., & Miller, E. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-05
- Volume
- 73
- Issue
- 5
- Pages
- 1674-1678
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2003731025
- Cited by
- 353
- References
- 0
- FWCI
- 23.69
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Changes in type of collagen synthesized as clones of chick chondrocytes grow and eventually lose division capacity. https://app.cochat.ai/papers/10.1073/pnas.73.5.1674
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- Mayne, R., Vail, M. S., Mayne, P. M., & Miller, E. J. (1976). Changes in type of collagen synthesized as clones of chick chondrocytes grow and eventually lose division capacity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.5.1674
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
