The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
beta-endorphin is a potent analgesic agent.
Open accessAbstract
beta-Endorphin, an opiate-like peptide, has potent antinociceptive properties when it is administered directly into the brain and assayed in the the tail-flick, hot-plate, and writhing tests in mice and in the wet shake test in rats. On a molar basis, beta-endorphin is 18 to 33 times more potent than morphine and its actions are blocked by the specific opiate antagonist, naloxone hydrochloride. The activity of beta-endorphin in vivo is also compared to other peptides that show opiate-like activity in assays in vitro.
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Citations
Cites
Identification of two related pentapeptides from the brain with potent opiate agonist activity
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806
Cited by
Brainstem Control of Spinal Pain-Transmission Neurons
Fields, H. L., & Basbaum, A. I. (1978) · Annual Review of Physiology · doi:10.1146/annurev.ph.40.030178.001245 · Cited by 831
Foot-shock induced stress increases β-endorphin levels in blood but not brain
ROSSIER, J., FRENCH, E. D., RIVIER, C., LING, N., GUILLEMIN, R., & BLOOM, F. E. (1977) · Nature · doi:10.1038/270618a0 · Cited by 578
Peptides in the Brain: The New Endocrinology of the Neuron
Guillemin, R. (1978) · Science · doi:10.1126/science.212832 · Cited by 485
The C-Fragment of β-Lipotropin: An Endogenous Neuroleptic or Antipsychotogen?
Jacquet, Y. F., & Marks, N. (1976) · Science · doi:10.1126/science.185695 · Cited by 425
β-Endorphin as a potent analgesic by intravenous injection
TSENG, L.-F., LOH, H. H., & LI, C. H. (1976) · Nature · doi:10.1038/263239a0 · Cited by 280
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Metadata
- Authors
- Loh, H. H., Tseng, L. F., Wei, E., & Li, C. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-08
- Volume
- 73
- Issue
- 8
- Pages
- 2895-2898
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2041935994
- Cited by
- 478
- References
- 1
- FWCI
- 16.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Loh, H. H., Tseng, L. F., Wei, E., & Li, C. H. (1976). beta-endorphin is a potent analgesic agent. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.8.2895
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
