The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
The C-Fragment of β-Lipotropin: An Endogenous Neuroleptic or Antipsychotogen?
Abstract
Microinjection of the C-fragment (also called β-endorphin), which is amino acid sequence 61-91 of the endogenous pituitary hormone, β-lipotropin (β-LPH), in the periaqueductal gray of the rat resulted in profound sedation and catalepsy, while microinjection of smaller fragments—that is, methionine-enkephalin [sequence β-LPH-(61-65)] and its related pentapeptide, leucine enkephalin, and α-endorphin [sequence β-LPH-(61-76)] resulted in attenuated forms of this behavior. This indicates that the C-fragment is an important neuromodulator of the central nervous system. The similarity of this behavior to that seen after systemic administration to experimental animals of exogenous neuroleptics suggests that a disturbance in the bioavailability of this neuropeptide to receptor sites in brain-perhaps due to lack of enzymatic cleavage from the circulating parent hormone, β-lipotropin—may be an etiological factor in those psychopathological states for which the exogenous neuroleptics exert an ameliorative influence.
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Citations
Cites
Opiate Receptor: Demonstration in Nervous Tissue
Pert, C. B., & Snyder, S. H. (1973) · Science · doi:10.1126/science.179.4077.1011 · Cited by 2,388
Hughes, J. (1975) · Brain Research · doi:10.1016/0006-8993(75)90391-1 · Cited by 982
Analgesia induced in vivo by central administration of enkephalin in rat
BELLUZZI, J. D., GRANT, N., GARSKY, V., SARANTAKIS, D., WISE, C. D., & STEIN, L. (1976) · Nature · doi:10.1038/260625a0 · Cited by 529
C fragment of lipotropin has a high affinity for brain opiate receptors
BRADBURY, A. F., SMYTH, D. G., SNELL, C. R., BIRDSALL, N. J. M., & HULME, E. C. (1976) · Nature · doi:10.1038/260793a0 · Cited by 489
beta-endorphin is a potent analgesic agent.
Loh, H. H., Tseng, L. F., Wei, E., & Li, C. H. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.8.2895 · Cited by 478
Autoradiographic localization of the opiate receptor in rat brain
Pert, C. B., Kuhar, M. J., & Snyder, S. H. (1975) · Life Sciences · doi:10.1016/0024-3205(75)90289-1 · Cited by 387
Paradoxical Effects after Microinjection of Morphine in the Periaqueductal Gray Matter in the Rat
Jacquet, Y. F., & Lajtha, A. (1974) · Science · doi:10.1126/science.185.4156.1055 · Cited by 268
Self-citationEvidence for analgesic activity of enkephalin in the mouse
BÜSCHER, H. H., HILL, R. C., RÖMER, D., CARDINAUX, F., CLOSSE, A., HAUSER, D., & PLESS, J. (1976) · Nature · doi:10.1038/261423a0 · Cited by 253
Chang, J.-K., Fong, B. T. W., Pert, A., & Pert, C. B. (1976) · Life Sciences · doi:10.1016/0024-3205(76)90366-0 · Cited by 217
beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins.
Lazarus, L. H., Ling, N., & Guillemin, R. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.6.2156 · Cited by 206
Cited by
β-Endorphin and Adrenocorticotropin Are Selected Concomitantly by the Pituitary Gland
Guillemin, R., Vargo, T., Rossier, J., Minick, S., Ling, N., Rivier, C., Vale, W., & Bloom, F. (1977) · Science · doi:10.1126/science.197601 · Cited by 1,419
A perceptual-defensive-recuperative model of fear and pain
Bolles, R. C., & Fanselow, M. S. (1980) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0000491x · Cited by 832
Dose-dependent reductions by naloxone of analgesia induced by cold-water stress
Bodnar, R. J., Kelly, D. D., Spiaggia, A., Ehrenberg, C., & Glusman, M. (1978) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(78)90264-2 · Cited by 310
CNS effects of peripherally administered brain peptides
Kastin, A. J., Olson, R. D., Schally, A. V., & Coy, D. H. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90572-1 · Cited by 277
Frederickson, R. C. A. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90421-0 · Cited by 269
Metadata
- Authors
- Jacquet, Y. F., & Marks, N.
- Venue
- Science
- Published
- 1976-11-05
- Volume
- 194
- Issue
- 4265
- Pages
- 632-635
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1988751611
- Cited by
- 425
- References
- 14
- FWCI
- 22.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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