The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Diphenylhydantoin (dilantin) gingival hyperplasia: drug-induced abnormality of connective tissue.
Open accessAbstract
Various degrees of gingival overgrowth may occur in individuals taking diphenylhydantoin, a drug used widely in the treatment of epilepsy. The tissue overgrowth is made up predominantly of collagen, and may therefore be a useful model for analysis of fibrosis and some other connective tissue abnormalities. Fibroblasts derived from the overgrown tissue exhibit a level of protein synthetic activity approximately twice that of comparable cells obtained from nonepileptic control individuals and from the gingiva of age-matched epileptics taking the drug but not exhibiting gingival enlargement. In addition, 20% of the protein synthesized by cells from the affected tissue is collagen, whereas collagen accounts for only about 11% of the total protein produced by control cells of both types. The drug appears to induce or select for fibroblasts characterized by enhanced levels of protein synthesis and collagen production. This alteration persists through several cell replications in vitro in the absence of drug.
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Citations
Cites
Connective tissue synthesis by scleroderma skin fibroblasts in cell culture
Leroy, E. C. (1972) · The Journal of Experimental Medicine · doi:10.1084/jem.135.6.1351 · Cited by 201
Cited by
Informational Paper: Drug‐Associated Gingival Enlargement
(2004) · Journal of Periodontology · doi:10.1902/jop.2004.75.10.1424 · Cited by 201
Hallmon, W. W., & Rossmann, J. A. (1999) · Periodontology 2000 · doi:10.1111/j.1600-0757.1999.tb00175.x · Cited by 148
Gingival Overgrowth in Children: Epidemiology, Pathogenesis, and Complications. A Literature Review
Doufexi, A., Mina, M., & Ioannidou, E. (2005) · Journal of Periodontology · doi:10.1902/jop.2005.76.1.3 · Cited by 146
Mechanism of drug‐induced gingival overgrowth revisited: a unifying hypothesis
Brown, R., & Arany, P. (2015) · Oral Diseases · doi:10.1111/odi.12264 · Cited by 97
Mimura, Y., Ihn, H., Jinnin, M., Asano, Y., Yamane, K., & Tamaki, K. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23701.x · Cited by 70
Metadata
- Authors
- Hassell, T. M., Page, R. C., Narayanan, A. S., & Cooper, C. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-08
- Volume
- 73
- Issue
- 8
- Pages
- 2909-2912
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2011694438
- Cited by
- 215
- References
- 1
- FWCI
- 32.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Hassell, T. M., Page, R. C., Narayanan, A. S., & Cooper, C. G. (1976). Diphenylhydantoin (dilantin) gingival hyperplasia: drug-induced abnormality of connective tissue. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.8.2909
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
