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A new method for sequencing DNA.
Open accessAbstract
DNA can be sequenced by a chemical procedure that breaks a terminally labeled DNA molecule partially at each repetition of a base. The lengths of the labeled fragments then identify the positions of that base. We describe reactions that cleave DNA preferentially at guanines, at adenines, at cytosines and thymines equally, and at cytosines alone. When the products of these four reactions are resolved by size, by electrophoresis on a polyacrylamide gel, the DNA sequence can be read from the pattern of radioactive bands. The technique will permit sequencing of at least 100 bases from the point of labeling.
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Cited by
DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Melton, D. A., Krieg, P. A., Rebagliati, M. R., Maniatis, T., Zinn, K., & Green, M. R. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.18.7035 · Cited by 6,324
Toward understanding the origin and evolution of cellular organisms
Kanehisa, M. (2019) · Protein Science · doi:10.1002/pro.3715 · Cited by 5,509
A vision for the future of genomics research
Collins, F. S., Green, E. D., Guttmacher, A. E., Guyer, M. S., & on behalf of the US National Human Genome Research Institute (2003) · Nature · doi:10.1038/nature01626 · Cited by 1,752
Metadata
- Authors
- Maxam, A. M., & Gilbert, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1977-02
- Volume
- 74
- Issue
- 2
- Pages
- 560-564
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1992595091
- Cited by
- 7,922
- References
- 0
- FWCI
- 201.72
- Type
- journal article
- Language
- en
- Open access
- green
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