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Granulocyte collagenase: selective digestion of type I relative to type III collagen.
Open accessAbstract
Collagenases produced by human polymorphonuclear leukocytes, human lung fibroblasts, and rabbit pulmonary alveolar macrophages were compared in their ability to digest soluble native type I and type III collagens. While the fibroblast and macrophage collagenases attacked the two substrates at approximately equal rates, the leukocyte collagenase attacked type I collagen preferentially (15:1) in comparison to type III collagen. This was true with human or rabbit collagen substrates. Thus, proteolysis of collagen, particularly in acute inflammation, may have a significant role in controlling the types of collagen present in connective tissue.
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Citations
Cited by
Role of collagenous matrices in the adhesion and growth of cells.
Kleinman, H. K., Klebe, R. J., & Martin, G. R. (1981) · The Journal of cell biology · doi:10.1083/jcb.88.3.473 · Cited by 1,361
Macrophages and Polymorphonuclear Neutrophils in Lung Defense and Injury
Sibille, Y., & Reynolds, H. Y. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.2.471 · Cited by 1,083
The collagen substrate specificity of human skin fibroblast collagenase.
Welgus, H. G., Jeffrey, J. J., & Eisen, A. Z. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68792-2 · Cited by 370
Junqueira, L. C. U., Zugaib, M., Montes, G. S., Toledo, O. M. S., Krisztán, R. M., & Shigihara, K. M. (1980) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(80)90248-3 · Cited by 364
Matrix Metalloproteinases: The Clue to Intervertebral Disc Degeneration?
Goupille, P., Jayson, M. I. V., Valat, J.-P., & Freemont, A. J. (1998) · Spine · doi:10.1097/00007632-199807150-00021 · Cited by 287
Metadata
- Authors
- Horwitz, A. L., Hance, A. J., & Crystal, R. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1977-03
- Volume
- 74
- Issue
- 3
- Pages
- 897-901
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1966328299
- Cited by
- 204
- References
- 0
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Granulocyte collagenase: selective digestion of type I relative to type III collagen. https://app.cochat.ai/papers/10.1073/pnas.74.3.897
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- Horwitz, A. L., Hance, A. J., & Crystal, R. G. (1977). Granulocyte collagenase: selective digestion of type I relative to type III collagen. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.74.3.897
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
