The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Uterine peroxidase as a marker for estrogen action.
Open accessAbstract
Administration of a single dose of estradiol to immature rats gives rise to the appearance of substantial amounts of peroxidase (donor:hydrogen-peroxide oxidoreductase, EC 1.11.1.7) enzyme activity in the uterus. This enzyme induction, which is inhibited by administration of actinomycin D and cycloheximide, can be detected at 4 hr after administration of estradiol, reaches a maximum level by 20 hr, and thereafter declines. The amount of uterine peroxidase seen at 20 hr after a single dose increases with dose from 0.1 to 100 microgram of estradiol. Estrone and estriol also show dose-dependent induction of peroxidase, and the quantitative peroxidase responses to these steroids follow their uterotropic capacities. The antiestrogen CI628, capable of low levels of enzyme induction by itself, can inhibit the induction due to estrogen. Solubilization of the uterine enzyme with divalent cations, especially calcium, results in a substantially increased yield of peroxidase. This extraction method provides an enzyme of about 50,000 molecular weight in distinction to the large aggregated form obtained by the usual extraction with sodium chloride.
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Cites
Burton, K. (1956) · Biochemical Journal · doi:10.1042/bj0620315 · Cited by 14,090
Cited by
Oxidative stress and antioxidants: exposure and impact on female fertility
Ruder, E. H., Hartman, T. J., Blumberg, J., & Goldman, M. B. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn011 · Cited by 351
In Vitro Bioassays for Assessing Estrogenic Substances
Zacharewski (1997) · Environmental Science & Technology · doi:10.1021/es960530o · Cited by 326
Free radical generation by redox cycling of estrogens
Liehr, J. G., & Roy, D. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90108-u · Cited by 295
Metadata
- Authors
- Lyttle, C. R., & DeSombre, E. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1977-08
- Volume
- 74
- Issue
- 8
- Pages
- 3162-3166
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2141749673
- Cited by
- 158
- References
- 1
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Lyttle, C. R., & DeSombre, E. R. (1977). Uterine peroxidase as a marker for estrogen action. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.74.8.3162
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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