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Addition of colchicine-tubulin complex to microtubule ends: The mechanism of substoichiometric colchicine poisoning
Open accessAbstract
Colchicine blocks microtubule polymerization by an unusual substoichiometric poisoning mechanism. We have investigated the mechanism by which this poisoning occurs with several experimental approaches, and have found that colchicine acts by addition to microtubule ends as a colchicine-tubulin complex.
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Citations
Cited by
Vallee, R. B. (1982) · The Journal of cell biology · doi:10.1083/jcb.92.2.435 · Cited by 551
Assembly of microtubules at the tip of growing axons
Bamburg, J. R., Bray, D., & Chapman, K. (1986) · Nature · doi:10.1038/321788a0 · Cited by 276
Dehio, C., Meyer, M., Berger, J., Schwarz, H., & Lanz, C. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.18.2141 · Cited by 209
Acetaldehyde substoichiometrically inhibits bovine neurotubulin polymerization.
Smith, S. L., Jennett, R. B., Sorrell, M. F., & Tuma, D. J. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114159 · Cited by 73
All Wired Up: An Exploration of the Electrical Properties of Microtubules and Tubulin
Kalra, A. P., Eakins, B. B., Patel, S. D., Ciniero, G., Rezania, V., Shankar, K., & Tuszynski, J. A. (2020) · ACS Nano · doi:10.1021/acsnano.0c06945 · Cited by 49
Metadata
- Authors
- Margolis, R. L., & Wilson, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1977-08
- Volume
- 74
- Issue
- 8
- Pages
- 3466-3470
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2016520189
- Cited by
- 285
- References
- 0
- FWCI
- 9.11
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Addition of colchicine-tubulin complex to microtubule ends: The mechanism of substoichiometric colchicine poisoning. https://app.cochat.ai/papers/10.1073/pnas.74.8.3466
- The paper
- Margolis, R. L., & Wilson, L. (1977). Addition of colchicine-tubulin complex to microtubule ends: The mechanism of substoichiometric colchicine poisoning. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.74.8.3466
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
