The DOI matches its Crossref record.
Variants of 3T3 cells lacking mitogenic response to epidermal growth factor.
Open accessAbstract
We have previously demonstrated that epidermal growth factor (EGF) can serve as a potent mitogen for 3T3 cells. We have now selected variant 3T3 cell lines unable to respond to EGF, in order to define cellular events unique to the EGF response and to distinguish which of these events are necessary and which are merely correlative to mitogenesis. By simultaneously treating cells with EGF and colchicine, we eliminated those cells stimulated by EGF to enter mitosis. Of the eight clonal EGF nonresponder variants selected by this procedure, none retains a functional EGF receptor. The EGF nonresponsive va-riant lines still retain the ability to respond to other mitogens.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Di Fiore, P. P., Pierce, J. H., Fleming, T. P., Hazan, R., Ullrich, A., King, C. R., Schlessinger, J., & Aaronson, S. A. (1987) · Cell · doi:10.1016/0092-8674(87)90592-7 · Cited by 640
Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus
Koo, L. Y., Irvine, D. J., Mayes, A. M., Lauffenburger, D. A., & Griffith, L. G. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.7.1423 · Cited by 420
Epidermal growth factor receptors
Adamson, E. D., & Rees, A. R. (1981) · Molecular and Cellular Biochemistry · doi:10.1007/bf02359619 · Cited by 349
Mellinghoff, I. K., Vivanco, I., Kwon, A., Tran, C., Wongvipat, J., & Sawyers, C. L. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.031 · Cited by 344
Domains of laminin with growth-factor activity
Panayotou, G., End, P., Aumailley, M., Timpl, R., & Engel, J. (1989) · Cell · doi:10.1016/0092-8674(89)90987-2 · Cited by 341
Metadata
- Authors
- Pruss, R. M., & Herschman, H. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1977-09
- Volume
- 74
- Issue
- 9
- Pages
- 3918-3921
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2126818181
- Cited by
- 274
- References
- 0
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Variants of 3T3 cells lacking mitogenic response to epidermal growth factor. https://app.cochat.ai/papers/10.1073/pnas.74.9.3918
- The paper
- Pruss, R. M., & Herschman, H. R. (1977). Variants of 3T3 cells lacking mitogenic response to epidermal growth factor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.74.9.3918
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
