HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability.

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ <i>neu</i> Oncogene

Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., & McGuire, W. L. (1987) · Science · doi:10.1126/science.3798106 · Cited by 11,760 · see citing works

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262 · see citing works

Sequence and structure-based prediction of eukaryotic protein phosphorylation sites

Blom, N., Gammeltoft, S., & Brunak, S. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3310 · Cited by 3,197 · see citing works

The ErbB signaling network: receptor heterodimerization in development and cancer

Olayioye, M. A., Neve, R. M., Lane, H. A., & Hynes, N. E. (2000) · The EMBO Journal · doi:10.1093/emboj/19.13.3159 · Cited by 2,438 · see citing works

Molecular determinants of resistance to antiandrogen therapy

Chen, C. D., Welsbie, D. S., Tran, C., Baek, S. H., Chen, R., Vessella, R., Rosenfeld, M. G., & Sawyers, C. L. (2004) · Nature Medicine · doi:10.1038/nm972 · Cited by 2,278 · see citing works

Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase

Kato, S., Endoh, H., Masuhiro, Y., Kitamoto, T., Uchiyama, S., Sasaki, H., Masushige, S., Gotoh, Y., Nishida, E., Kawashima, H., et al. (1995) · Science · doi:10.1126/science.270.5241.1491 · Cited by 1,964 · see citing works

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

Yamamoto, K. K., Gonzalez, G. A., Biggs, W., & Montminy, M. (1988) · Nature · doi:10.1038/334494a0 · Cited by 1,281 · see citing works

A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase

Craft, N., Shostak, Y., Carey, M., & Sawyers, C. L. (1999) · Nature Medicine · doi:10.1038/6495 · Cited by 980 · see citing works

The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation

Holbro, T., Beerli, R. R., Maurer, F., Koziczak, M., Barbas, C. F., & Hynes, N. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1537685100 · Cited by 952 · see citing works

Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor.

Čulig, Z., Hobisch, A., Cronauer, M. V., Radmayr, C., Trapman, J., Hittmair, A., Bartsch, G., & Klocker, H. (1994) · PubMed · Cited by 938 · see citing works

Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth

Agus, D. B., Akita, R. W., Fox, W. D., Lewis, G. D., Higgins, B., Pisacane, P. I., Lofgren, J. A., Tindell, C., Evans, D. P., Maiese, K., et al. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00097-1 · Cited by 873 · see citing works

A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

Fry, D. W., Kraker, A. J., McMichael, A., Ambroso, L. A., Nelson, J. M., Leopold, W. R., Connors, R. W., & Bridges, A. J. (1994) · Science · doi:10.1126/science.8066447 · Cited by 806 · see citing works

The Androgen Axis in Recurrent Prostate Cancer

Mohler, J. L., Gregory, C. W., Ford, O. H., Kim, D., Weaver, C. M., Petrusz, P., Wilson, E. M., & French, F. S. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-1146-03 · Cited by 675 · see citing works

Formation of the Androgen Receptor Transcription Complex

Shang, Y., Myers, M., & Brown, M. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00471-9 · Cited by 673 · see citing works

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.

Sliwkowski, M. X., Schaefer, G., Akita, R. W., Lofgren, J. A., Fitzpatrick, V. D., Nuijens, A., FENDLY, B. M., Cerione, R. A., VANDLEN, R. L., & Carraway, K. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36676-0 · Cited by 644 · see citing works

From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells

Yeh, S., Lin, H., Kang, H., Thin, T. H., Lin, M., & Chang, C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5458 · Cited by 594 · see citing works

Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist.

Taplin, M., Bubley, G. J., Ko, Y., Small, E. J., Upton, M. P., Rajeshkumar, B. R., & Balk, S. P. (1999) · PubMed · Cited by 594 · see citing works

Proteasome-dependent degradation of the human estrogen receptor

Nawaz, Z., Lonard, D. M., Dennis, A. P., Smith, C. L., & O’Malley, B. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.1858 · Cited by 589 · see citing works

Untitled work

(2001) · PubMed · Cited by 500 · see citing works

HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.

Wen, Y., Hu, M. C. ‐., Makino, K., Spohn, B., Bartholomeusz, G. A., Yan, D., & Hung, M. (2000) · PubMed · Cited by 461 · see citing works

Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome

Lange, C. A., Shen, T., & Horwitz, K. B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1032 · Cited by 451 · see citing works

Phosphorylation‐dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase

Lin, H.-K., Wang, L., Hu, Y., Altuwaijri, S., & Chang, C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf406 · Cited by 450 · see citing works

The Angelman Syndrome-Associated Protein, E6-AP, Is a Coactivator for the Nuclear Hormone Receptor Superfamily

Nawaz, Z., Lonard, D. M., Smith, C. L., Lev-Lehman, E., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1182 · Cited by 445 · see citing works

AIB1 Is a Conduit for Kinase-Mediated Growth Factor Signaling to the Estrogen Receptor

de Mora, J. F., & Brown, M. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5041-5047.2000 · Cited by 432 · see citing works

Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones.

Kemppainen, J., Lane, M. V., Sar, M., & Wilson, E. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48380-9 · Cited by 430 · see citing works

Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer

Edwards, J., Krishna, N. S., Grigor, K. M., & Bartlett, J. M. S. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601127 · Cited by 425 · see citing works

Lactacystin, Proteasome Function, and Cell Fate

Fenteany, G., & Schreiber, S. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8545 · Cited by 414 · see citing works

Two Androgen Response Regions Cooperate in Steroid Hormone Regulated Activity of the Prostate-specific Antigen Promoter

Cleutjens, K. B. J. M., Eekelen, C. C. E.-V., van der Korput, H. A. G. M., Brinkmann, A. O., & Trapman, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6379 · Cited by 408 · see citing works

Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.

Lin, H.-K., Yeh, S., Kang, H.-Y., & Chang, C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121173298 · Cited by 401 · see citing works

Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice

Klein, K. A., Reiter, R. E., Redula, J., Moradi, H., Zhu, X. L., Brothman, A. R., Lamb, D. J., Marcelli, M., Belldegrun, A. S., Witte, O. N., et al. (1997) · Nature Medicine · doi:10.1038/nm0497-402 · Cited by 399 · see citing works

Her-2-neu Expression and Progression Toward Androgen Independence in Human Prostate Cancer

Signoretti, S. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.23.1918 · Cited by 397 · see citing works

An Androgen Response Element in a Far Upstream Enhancer Region Is Essential for High, Androgen-Regulated Activity of the Prostate-Specific Antigen Promoter

Cleutjens, K. B. J. M., van der Korput, H. A. G. M., Eekelen, C. C. E.-V., van Rooij, H. C. J., Faber, P. W., & Trapman, J. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.2.9883 · Cited by 375 · see citing works

Androgen Receptor Phosphorylation

Gioeli, D. G., Ficarro, S. B., Kwiek, J. J., Aaronson, D. S., Hancock, M., Catling, A. D., White, F. M., Christian, R. E., Settlage, R. E., Shabanowitz, J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204131200 · Cited by 355 · see citing works

The epidermal growth factor receptor as a target for cancer therapy.

Mendelsohn, J. M. (2001) · Endocrine Related Cancer · doi:10.1677/erc.0.0080003 · Cited by 330 · see citing works

Tyrosine kinase inhibitors: From rational design to clinical trials

Traxler, P. M., Bold, G., Buchdunger, E., Caravatti, G., Furet, P., Manley, P. W., O’Reilly, T., Wood, J. M., & Zimmermann, J. (2001) · Medicinal Research Reviews · doi:10.1002/med.1022 · Cited by 325 · see citing works

Variants of 3T3 cells lacking mitogenic response to epidermal growth factor.

Pruss, R. M., & Herschman, H. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.9.3918 · Cited by 277 · see citing works

Phosphorylation of Steroid Receptor Coactivator-1

Rowan, B. G., Weigel, N. L., & O’Malley, B. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4475 · Cited by 267 · see citing works

Phosphorylation of Human Estrogen Receptor α by Protein Kinase A Regulates Dimerization

Chen, D., Pace, P. E., Coombes, R. C., & Ali, S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1002 · Cited by 258 · see citing works

Serum prostate specific antigen levels in mice bearing human prostate LNCaP tumors are determined by tumor volume and endocrine and growth factors.

Gleave, M. E., Hsieh, J. T., Wu, H. C., von Eschenbach, A. C., & Chung, L. W. K. (1992) · PubMed · Cited by 226 · see citing works

THE PROSTATE: DEVELOPMENT AND PHYSIOLOGY

Hayward, S. W., & Cunha, G. R. (2000) · Radiologic Clinics of North America · doi:10.1016/s0033-8389(05)70146-9 · Cited by 218 · see citing works

The SMRT Corepressor Is Regulated by a MEK-1 Kinase Pathway: Inhibition of Corepressor Function Is Associated with SMRT Phosphorylation and Nuclear Export

Hong, S.-H., & Privalsky, M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.17.6612-6625.2000 · Cited by 215 · see citing works

Changing pattern of expression of the epidermal growth factor receptor and transforming growth factor alpha in the progression of prostatic neoplasms.

Scher, H. I., Sarkis, A. S., Reuter, V., Cohen, D., Netto, G. J., Petrylak, D. P., LIANES, P., FUKS, Z. Y., Mendelsohn, J. M., & Cordon‐Cardo, C. (1995) · PubMed · Cited by 214 · see citing works

Epidermal Growth Factor Increases Coactivation of the Androgen Receptor in Recurrent Prostate Cancer

Gregory, C. W., Fei, X., Ponguta, L. A., He, B., Bill, H. M., French, F. S., & Wilson, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307649200 · Cited by 201 · see citing works

Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation

Lipford, J., & Deshaies, R. (2003) · Nature Cell Biology · doi:10.1038/ncb1003-845 · Cited by 195 · see citing works

MAP Kinase-Dependent Transcriptional Coactivation by Elk-1 and Its Cofactor CBP

Janknecht, R., & Nordheim, A. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1740 · Cited by 191 · see citing works

Suppression Versus Induction of Androgen Receptor Functions by the Phosphatidylinositol 3-Kinase/Akt Pathway in Prostate Cancer LNCaP Cells with Different Passage Numbers

Lin, H., Hu, Y., Yang, L., Altuwaijri, S., Chen, Y.-T., Kang, H., & Chang, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300676200 · Cited by 187 · see citing works

Androgen receptor outwits prostate cancer drugs

Isaacs, J. T., & Isaacs, W. B. (2003) · Nature Medicine · doi:10.1038/nm0104-26 · Cited by 181 · see citing works

Phosphorylation of serum response factor, a factor that binds to the serum response element of the c-FOS enhancer.

Prywes, R., Dutta, A., Cromlish, J. A., & Roeder, R. G. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7206 · Cited by 173 · see citing works

HER-2/neu (p185neu) protein expression in the natural or treated history of prostate cancer.

Osman, I., Scher, H. I., Drobnjak, M., Verbel, D., Morris, M. J., Agus, D. B., Ross, J. S., & Cordon‐Cardo, C. (2001) · PubMed · Cited by 161 · see citing works

Modulation of glucocorticoid receptor function by protein kinase A.

Rangarajan, P. N., Umesono, K., & Evans, R. M. (1992) · Molecular Endocrinology · doi:10.1210/mend.6.9.1435789 · Cited by 159 · see citing works

Androgen-induced recruitment of RNA polymerase II to a nuclear receptor–p160 coactivator complex

Louie, M. C., Yang, H. Q., Ma, A., Xu, W., Zou, J. X., Kung, H.-J., & Chen, H.-W. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437824100 · Cited by 157 · see citing works

Growth Factors Signal to Steroid Receptors through Mitogen-activated Protein Kinase Regulation of p160 Coactivator Activity

Lopez, G. N., Turck, C. W., Schaufele, F., Stallcup, M. R., & Kushner, P. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010718200 · Cited by 150 · see citing works

Response of prostate cancer to anti-Her-2/neu antibody in androgen-dependent and -independent human xenograft models.

Agus, D. B., Scher, H. I., Higgins, B., Fox, W. D., Heller, G., Fazzari, M. J., Cordon‐Cardo, C., & Golde, D. W. (1999) · PubMed · Cited by 143 · see citing works

Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3-Kinase in Mouse Fibroblasts Transfected with erbB2/neu and erbB3

Carraway, K. L., Soltoff, S. P., Diamonti, A. J., & Cantley, L. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7111 · Cited by 139 · see citing works

Postnatal Development of the Testis, Fighting Behavior, and Fertility in House Mice1

McKinney, T. D., & Desjardins, C. (1973) · Biology of Reproduction · doi:10.1093/biolreprod/9.3.279 · Cited by 123 · see citing works

HER-2/NEU EXPRESSION IN PROSTATE CANCER: HIGH LEVEL OF EXPRESSION ASSOCIATED WITH EXPOSURE TO HORMONE THERAPY AND ANDROGEN INDEPENDENT DISEASE

Shi, Y., Brands, F., CHATTERJEE, S., Feng, A., Groshen, S. G., Schewe, J., Lieskovsky, G., & Côté, R. J. (2001) · The Journal of Urology · doi:10.1016/s0022-5347(05)65822-3 · Cited by 122 · see citing works

Modulating nuclear receptor function: may the phos be with you

Shao, D., & Lazar, M. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7421 · Cited by 118 · see citing works

Inhibiting Proteasomes in Human HepG2 and LNCaP Cells Increases Endogenous Androgen Receptor Levels

Sheflin, L. G., Keegan, B. P., Zhang, W., & Spaulding, S. W. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3424 · Cited by 114 · see citing works

The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B.

Hirata, Y., Kiuchi, K., Chen, H. C., Milbrandt, J., & Guroff, G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74536-0 · Cited by 112 · see citing works

Expression and Gene Copy Number Analysis of ERBB2 Oncogene in Prostate Cancer

Savinainen, K., Saramäki, O. R., Linja, M. J., Ola Bratt, A., Tammela, T. L. J., Isola, J. J., & Visakorpi, T. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64377-5 · Cited by 90 · see citing works

Growth inhibitory effects of the dual ErbB1/ErbB2 tyrosine kinase inhibitor PKI-166 on human prostate cancer xenografts.

Mellinghoff, I. K., Tran, C., & Sawyers, C. L. (2002) · PubMed · Cited by 88 · see citing works

Modulation of glucocorticoid receptor function by protein kinase A

Rangarajan, P. N. (1992) · Molecular Endocrinology · doi:10.1210/me.6.9.1451 · Cited by 77 · see citing works

Functional Regulation of Thyroid Hormone Receptor Variant TRα2 by Phosphorylation

Katz, D., Reginato, M. J., & Lazar, M. A. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.5.2341 · Cited by 76 · see citing works

Human epidermal receptor-2 expression in prostate cancer.

Calvo, B. F., LEVINE, A. M., Marcos, M., Collins, Q. F., Iacocca, M., Caskey, L. S., Gregory, C. W., Lin, Y., Whang, Y. E., Earp, H. S., et al. (2003) · PubMed · Cited by 66 · see citing works

The PTEN tumor suppressor is a negative modulator of androgen receptor transcriptional activity

Nan, B., Snabboon, T., Unni, E., X-J, Y., Whang, Y. E., & Marcelli, M. (2003) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0310169 · Cited by 63 · see citing works

Phosphorylation enhances the target gene sequence-dependent dimerization of thyroid hormone receptor with retinoid X receptor.

Bhat, M. K., Ashizawa, K., & Cheng, S.-Y. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.7927 · Cited by 61 · see citing works

Phosphorylation selectively increases triiodothyronine receptor homodimer binding to DNA.

Sugawara, A., Yen, P. M., Apriletti, J. W., Ribeiro, R. C., Sacks, D. B., Baxter, J. D., & Chin, W. W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42369-6 · Cited by 60 · see citing works

Phosphorylation of androgen receptor isoforms.

Wong, H.-Y., Burghoorn, J., van Leeuwen, M., de Ruiter, P. D., Schippers, E., Blok, L., Li, K.-W., Dekker, H. L., de Jong, L., Trapman, J., et al. (2004) · Biochemical Journal · doi:10.1042/bj20040683 · Cited by 59 · see citing works

An antiestrogen: a phosphotyrosyl peptide that blocks dimerization of the human estrogen receptor.

Arnold, S. F., & Notides, A. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7475 · Cited by 55 · see citing works

Small-interfering RNAs in the radar of the interferon system

Moss, E. G., & Taylor, J. M. (2003) · Nature Cell Biology · doi:10.1038/ncb0903-771 · Cited by 52 · see citing works

Hormone-Dependent Regulation of Chicken Progesterone Receptor Deoxyribonucleic Acid Binding and Phosphorylation*

Denner, L. A., Weigel, N. L., Schrader, W. T., & O’Malley, B. W. (1989) · Endocrinology · doi:10.1210/endo-125-6-3051 · Cited by 48 · see citing works

An androgen response element mediates LNCaP cell dependent androgen induction of the hK2 gene

Mitchell, S. H., Murtha, P. E., Zhang, S., Zhu, W. B., & Young, C. Y. F. (2000) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00319-1 · Cited by 46 · see citing works

Phosphorylation of Thyroid Hormone Receptors by Protein Kinase A Regulates DNA Recognition by Specific Inhibition of Receptor Monomer Binding

Tzagarakis-Foster, C., & Privalsky, M. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.10926 · Cited by 43 · see citing works

Her-2/neu Expression in Prostate Cancer

Carles, J., Lloreta, J., Salido, M., Pous, A. F., Suarez, M., Baena, V., Nogué, M., Domènech, M., & Fabregat, X. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0115 · Cited by 38 · see citing works

Growth Factor Receptor Tyrosine Kinase Inhibitors; Clinical Development and Potential for Prostate Cancer Therapy

Blackledge, G. R. P. (2003) · The Journal of Urology · doi:10.1097/01.ju.0000095022.80033.d3 · Cited by 24 · see citing works

Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer

Carver, B. S., Chapinski, C., Wongvipat, J., Hieronymus, H., Chen, Y., Chandarlapaty, S., Arora, V. K., Le, C. H., Koutcher, J. A., Scher, H. I., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.04.008 · Cited by 1,197 · see citing works

Novel anticancer targets: revisiting ERBB2 and discovering ERBB3

Baselga, J. M., & Swain, S. M. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2656 · Cited by 1,145 · see citing works

Biology of Progressive, Castration-Resistant Prostate Cancer: Directed Therapies Targeting the Androgen-Receptor Signaling Axis

Scher, H. I., & Sawyers, C. L. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.4777 · Cited by 1,025 · see citing works

Androgen receptor: structure, role in prostate cancer and drug discovery

Tan, M.-H., Li, J., Xu, H. E., Melcher, K., & Yong, E. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.18 · Cited by 958 · see citing works

Molecular genetics of prostate cancer: new prospects for old challengesPreprint

Shen, M. M., & Abate-Shen, C. T. (2010) · Genes & Development · doi:10.1101/gad.1965810 · Cited by 949 · see citing works

Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches

Karantanos, T., Corn, P. G., & Thompson, T. C. (2013) · Oncogene · doi:10.1038/onc.2013.206 · Cited by 866 · see citing works

Identification of molecular apocrine breast tumours by microarray analysis

Farmer, P. J., Bonnefoi, H. R., Becette, V., Tubiana-Hulin, M., Fumoleau, P., Larsimont, D., MacGrogan, G. M., Bergh, J. C. S., Cameron, D., Goldstein, D., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208561 · Cited by 783 · see citing works

The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling

Shorning, B. Y., Dass, M. S., Smalley, M. J., & Pearson, H. B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124507 · Cited by 647 · see citing works

An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen

Doane, A. S., Danso, M. A., Lal, P., Donaton, M., Zhang, L., Hudis, C. A., & Gerald, W. L. (2006) · Oncogene · doi:10.1038/sj.onc.1209415 · Cited by 604 · see citing works

The role of HER2 in cancer therapy and targeted drug delivery

Tai, W., Mahato, R., & Cheng, K. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.04.009 · Cited by 557 · see citing works

Cutaneous side-effects of kinase inhibitors and blocking antibodies

Robert, C., Soria, J., Spatz, A., Cesne, A. L., Malka, D., Pautier, P., Wechsler, J., Lhommé, C., Escudier, B. J., Boige, V., et al. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70243-6 · Cited by 550 · see citing works

Androgen receptors in hormone-dependent and castration-resistant prostate cancer

Shafi, A. A., Yen, A. E., & Weigel, N. L. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.003 · Cited by 422 · see citing works

Androgen Signaling in Prostate CancerPreprint

Dai, C. S., Heemers, H. V., & Sharifi, N. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a030452 · Cited by 412 · see citing works

Targeting Androgen Receptor in Estrogen Receptor-Negative Breast Cancer

Ni, M., Chen, Y., Lim, E., Wimberly, H., Bailey, S. T., Imai, Y., Rimm, D. L., Liu, X. S., & Brown, M. A. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.05.026 · Cited by 398 · see citing works

Targeting the androgen receptor pathway in prostate cancer

Chen, Y., Sawyers, C. L., & Scher, H. I. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.07.005 · Cited by 393 · see citing works

Targeting the PI3K/AKT Pathway for the Treatment of Prostate Cancer

Sarker, D., Reid, A. H. M., Yap, T. A., & de Bono, J. S. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0125 · Cited by 366 · see citing works

Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target

Chen, Y., Clegg, N. J., & Scher, H. I. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70229-3 · Cited by 322 · see citing works

Targeting the PI3K/Akt/mTOR pathway in castration-resistant prostate cancer

Bitting, R. L., & Armstrong, A. J. (2013) · Endocrine Related Cancer · doi:10.1530/erc-12-0394 · Cited by 311 · see citing works

Androgen receptor and growth factor signaling cross-talk in prostate cancer cells.

Zhu, M.-L., & Kyprianou, N. (2008) · Endocrine Related Cancer · doi:10.1677/erc-08-0084 · Cited by 286 · see citing works

Understanding the Mechanisms of Androgen Deprivation Resistance in Prostate Cancer at the Molecular Level

Karantanos, T., Evans, C. P., TOMBAL, B. F., Thompson, T. C., Montironi, R., & Isaacs, W. B. (2014) · European Urology · doi:10.1016/j.eururo.2014.09.049 · Cited by 285 · see citing works

Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation.

Mahajan, N. P., Liu, Y., Majumder, S., Warren, M. R., Parker, C. E., Mohler, J. L., Earp, H. S., & Whang, Y. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700420104 · Cited by 274 · see citing works

Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer

Zhang, Z., Karthaus, W. R., Lee, Y. S., Gao, V. R., Wu, C., Russo, J. W., Liu, M., Mota, J. M., Abida, W. M., Linton, E. L., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.005 · Cited by 259 · see citing works

The ERBB3 receptor in cancer and cancer gene therapy

Sithanandam, G., & Anderson, L. M. (2008) · Cancer Gene Therapy · doi:10.1038/cgt.2008.15 · Cited by 240 · see citing works

Androgen receptor overexpression induces tamoxifen resistance in human breast cancer cells

Amicis, F. D., Janagi, T., Cui, Y., Selever, J., Beyer, A. R., Parra, I., Weigel, N. L., Herynk, M. H., Tsimelzon, A. I., Lewis, M. T., et al. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0436-8 · Cited by 229 · see citing works

Activated Tyrosine Kinase Ack1 Promotes Prostate Tumorigenesis: Role of Ack1 in Polyubiquitination of Tumor Suppressor Wwox

Mahajan, N. P., Whang, Y. E., Mohler, J. L., & Earp, H. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1127 · Cited by 228 · see citing works

Mechanisms of resistance to systemic therapy in metastatic castration-resistant prostate cancer

Galletti, G., Leach, B. I., Lam, L., & Tagawa, S. T. (2017) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2017.04.008 · Cited by 215 · see citing works

Bisphenol A affects androgen receptor function via multiple mechanisms

Teng, C. T., Goodwin, B. L., Shockley, K. R., Xia, M., Huang, R., Norris, J. D., Merrick, B. A., Jetten, A. M., Austin, C. P., & Tice, R. R. (2013) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2013.03.013 · Cited by 211 · see citing works

Mechanisms mediating androgen receptor reactivation after castration

Yuan, X., & Balk, S. P. (2008) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2008.03.021 · Cited by 204 · see citing works

Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1

Chen, S., Xu, Y., Yuan, X., Bubley, G. J., & Balk, S. P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604193103 · Cited by 202 · see citing works

Steroid Receptor Phosphorylation: A Key Modulator of Multiple Receptor Functions

Weigel, N. L., & Moore, N. L. T. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0101 · Cited by 196 · see citing works

Rapid Induction of Androgen Receptor Splice Variants by Androgen Deprivation in Prostate Cancer

Yu, Z., Chen, S., Sowalsky, A. G., Voznesensky, O. S., Mostaghel, E. A., Nelson, P. S., Cai, C., & Balk, S. P. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1863 · Cited by 194 · see citing works

Inhibition of the Androgen Receptor as a Novel Mechanism of Taxol Chemotherapy in Prostate Cancer

Gan, L., Chen, S., Wang, Y., Watahiki, A., Bohrer, L. R., Sun, Z. K., Wang, Y. Z., & Huang, H. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1504 · Cited by 197 · see citing works

Differential Expression of Hormonal and Growth Factor Receptors in Salivary Duct Carcinomas

Williams, M. D., Roberts, D. B., Blumenschein, G. R., Temam, S., Kies, M. S., Rosenthal, D. I., Weber, R. S., & El‐Naggar, A. K. (2007) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e3180caa099 · Cited by 191 · see citing works

Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide

Nickols, N. G., & Dervan, P. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704217104 · Cited by 189 · see citing works

Androgen action and metabolism in prostate cancer

Green, S. M., Mostaghel, E. A., & Nelson, P. S. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.046 · Cited by 182 · see citing works

Interleukin-6: A multifunctional targetable cytokine in human prostate cancer

Čulig, Z., & Puhr, M. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.05.033 · Cited by 172 · see citing works

Metastatic prostate cancer remains incurable, why?

Dong, L., Zieren, R. C., Xue, W., de Reijke, T. M., & Pienta, K. J. (2018) · Asian journal of urology · doi:10.1016/j.ajur.2018.11.005 · Cited by 167 · see citing works

miR-331-3p Regulates ERBB-2 Expression and Androgen Receptor Signaling in Prostate Cancer

Epis, M. R., Giles, K. M., Barker, A. J., Kendrick, T. S., & Leedman, P. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.030098 · Cited by 163 · see citing works

AR Signaling and the PI3K Pathway in Prostate Cancer

Crumbaker, M., Khoja, L., & Joshua, A. M. (2017) · Cancers · doi:10.3390/cancers9040034 · Cited by 163 · see citing works

A Functionally Significant Cross-talk between Androgen Receptor and ErbB2 Pathways in Estrogen Receptor Negative Breast Cancer

Naderi, A., & Hughes‐Davies, L. (2008) · Neoplasia · doi:10.1593/neo.08274 · Cited by 162 · see citing works

ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli

Tapinos, N., Ohnishi, M., & Rambukkana, A. (2006) · Nature Medicine · doi:10.1038/nm1433 · Cited by 153 · see citing works

Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies

Mimeault, M., & Batra, S. K. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi229 · Cited by 153 · see citing works

Molecular Mechanisms of ErbB2-Mediated Breast Cancer Chemoresistance

Tan, M., & Yu, D. (2007) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-74039-3_9 · Cited by 151 · see citing works

Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer

Lamont, K. R., & Tindall, D. J. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0469 · Cited by 150 · see citing works

Regulation of Survivin by ErbB2 Signaling: Therapeutic Implications for ErbB2-Overexpressing Breast Cancers

Xia, W., Bisi, J., Strum, J. C., Liu, L.-H., Carrick, K., Graham, K. M., Treece, A. L., Hardwicke, M. A., Dush, M. K., Liao, Q., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2000 · Cited by 150 · see citing works

Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability

Majumder, S., Liu, Y., Ford, O. H., Mohler, J. L., & Whang, Y. E. (2006) · The Prostate · doi:10.1002/pros.20438 · Cited by 146 · see citing works

Decreased Expression and Androgen Regulation of the Tumor Suppressor Gene INPP4B in Prostate Cancer

Hodgson, M. C., Shao, L.-J., Frolov, A., Li, R., Peterson, L. E., Ayala, G., Ittmann, M., Weigel, N. L., & Agoulnik, I. U. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2314 · Cited by 142 · see citing works

Androgen receptor action in hormone‐dependent and recurrent prostate cancer

Agoulnik, I. U., & Weigel, N. L. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20811 · Cited by 141 · see citing works

Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer.

Gao, H., Ouyang, X., Banach-Petrosky, W. A., Gerald, W. L., Shen, M. M., & Abate-Shen, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606836103 · Cited by 141 · see citing works

Expression and Nuclear Localization of ErbB3 in Prostate Cancer

Koumakpayi, I. H., Diallo, J., Page, C. L., Lessard, L., Gleave, M. E., Bégin, L. R., Mes‐Masson, A., & Fred Saad, C. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2242 · Cited by 140 · see citing works

Hepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen level

Chiu, C.-M., Yeh, S., Chen, P., Kuo, T.-J., Chang, C.-J., Chen, P., Yang, W., & Chen, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609498104 · Cited by 135 · see citing works

Open-Label Phase II Study Evaluating the Efficacy and Safety of Two Doses of Pertuzumab in Castrate Chemotherapy-Naive Patients With Hormone-Refractory Prostate Cancer

Bono, J. S. D., Joaquim Bellmunt, B., Attard, G., Droz, J. P., Miller, K., Fléchon, A., Sternberg, C. N., Parker, C. C., Zugmaier, G., Hersberger-Gimenez, V., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.0888 · Cited by 134 · see citing works

Apoptosis evasion: The role of survival pathways in prostate cancer progression and therapeutic resistance

McKenzie, S. P., & Kyprianou, N. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20634 · Cited by 130 · see citing works

Targeting the adaptive molecular landscape of castration‐resistant prostate cancer

Wyatt, A. W., & Gleave, M. E. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201303701 · Cited by 129 · see citing works

Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro

Robinson, M. K., Hodge, K. M., Horak, E. M., Sundberg, Å. L., Russeva, M., Shaller, C. C., von Mehren, M., Shchaveleva, I., Simmons, H. H., Marks, J. D., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604700 · Cited by 128 · see citing works

CXCL12/CXCR4 Transactivates HER2 in Lipid Rafts of Prostate Cancer Cells and Promotes Growth of Metastatic Deposits in Bone

Chinni, S., Yamamoto, H., Dong, Z.-Y., Sabbota, A. L., Bonfil, R., & Cher, M. L. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-0117 · Cited by 146 · see citing works

AR Signaling in Breast Cancer

Rahim, B. G., & O'Regan, R. M. (2017) · Cancers · doi:10.3390/cancers9030021 · Cited by 118 · see citing works

Signal transduction in prostate cancer progression

Gioeli, D. G. (2005) · Clinical Science · doi:10.1042/cs20040329 · Cited by 116 · see citing works

Regulation of androgen receptor levels: Implications for prostate cancer progression and therapy

Burnstein, K. L. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20460 · Cited by 117 · see citing works

Cellular prostatic acid phosphatase: a protein tyrosine phosphatase involved in androgen-independent proliferation of prostate cancer

Veeramani, S., Yuan, T., Chen, S.-J., Lin, F., Petersen, J. E., Shaheduzzaman, S., Srivastava, S. K., MacDonald, R. G., & Lin, M. (2005) · Endocrine Related Cancer · doi:10.1677/erc.1.00950 · Cited by 112 · see citing works

Site-specific Androgen Receptor Serine Phosphorylation Linked to Epidermal Growth Factor-dependent Growth of Castration-recurrent Prostate Cancer

Ponguta, L. A., Gregory, C. W., French, F. S., & Wilson, E. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802392200 · Cited by 112 · see citing works

Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer.

Lange, C., Gioeli, D., Hammes, S., & Marker, P. C. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.031905.160319 · Cited by 122 · see citing works

Regulation of Androgen Receptor and Prostate Cancer Growth by Cyclin-dependent Kinase 5

Hsu, F.-N., Chen, M. C., Chiang, M.-C., Lin, E., Lee, Y.-T., Huang, P.-H., Lee, G.-S., & Lin, H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.252080 · Cited by 108 · see citing works

Efficacy and Safety of Single-Agent Pertuzumab (rhuMAb 2C4), a Human Epidermal Growth Factor Receptor Dimerization Inhibitor, in Castration-Resistant Prostate Cancer After Progression From Taxane-Based Therapy

Agus, D. B., Sweeney, C. J., Morris, M. J., Mendelson, D. S., McNeel, D. G., Ahmann, F. R., Wang, J., Derynck, M. K., Ng, K., Lyons, B., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.0649 · Cited by 107 · see citing works

Dasatinib inhibits site-specific tyrosine phosphorylation of androgen receptor by Ack1 and Src kinases.

Liu, Y., Karaca, M., Zhang, Z., Gioeli, D., Earp, H. S., & Whang, Y. E. (2010) · Oncogene · doi:10.1038/onc.2010.103 · Cited by 106 · see citing works

Persistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions

Decker, K. F., Zheng, D., He, Y., Bowman, T. A., Edwards, J. R., & Li, J. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks888 · Cited by 104 · see citing works

Bioactive natural products for chemoprevention and treatment of castration-resistant prostate cancer

Kallifatidis, G., Hoy, J. J., & Lokeshwar, B. L. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.06.003 · Cited by 107 · see citing works

Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets

Fontana, F., Raimondi, M., Marzagalli, M., Domizio, A. D., & Limonta, P. (2020) · Cells · doi:10.3390/cells9020460 · Cited by 105 · see citing works

Dihydrotestosterone upregulates the expression of epidermal growth factor receptor and ERBB2 in androgen receptor-positive bladder cancer cells

Zheng, Y., Izumi, K., Yao, J. L., & Miyamoto, H. (2011) · Endocrine Related Cancer · doi:10.1530/erc-11-0010 · Cited by 104 · see citing works

Non-competitive androgen receptor inhibition in vitro and in vivo

Jones, J. O., Bolton, E. C., Huang, Y., Féau, C., Guy, R. K., Yamamoto, K. R., Hann, B. C., & Diamond, M. I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807282106 · Cited by 104 · see citing works

Downregulation of androgen receptor expression by luteolin causes inhibition of cell proliferation and induction of apoptosis in human prostate cancer cells and xenografts

Chiu, F., & Lin, J. (2007) · The Prostate · doi:10.1002/pros.20690 · Cited by 103 · see citing works

Androgen receptor is frequently expressed in HER2-positive, ER/PR-negative breast cancers

Micello, D., Marando, A., Sahnane, N., Riva, C., Capella, C., & Sessa, F. (2010) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-010-0964-y · Cited by 102 · see citing works

Androgen axis in prostate cancer.

Culig, Z., & Bartsch, G. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20898 · Cited by 102 · see citing works

Inhibition of HER-2/neu Kinase Impairs Androgen Receptor Recruitment to the Androgen Responsive Enhancer

Liu, Y., Majumder, S., McCall, W., Sartor, C. I., Mohler, J. L., Gregory, C. W., Earp, H. S., & Whang, Y. E. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4292 · Cited by 99 · see citing works

The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells

Zhang, Y., Wang, X. W., Jelovac, D., Nakanishi, T., Yu, M.-H., Akinmade, D., Goloubeva, O. G., Ross, D. D., Brodie, A. M. H., & Hamburger, A. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503829102 · Cited by 97 · see citing works

Androgen receptor (AR) expression in 400 breast carcinomas: is routine AR assessment justified?

Safarpour, D., Pakneshan, S., & Tavassoli, F. A. (2014) · Europe PMC (PubMed Central) · Cited by 97 · see citing works

Expression of androgen receptor splice variants in clinical breast cancers

Hickey, T. E., Irvine, C. M., Dvinge, H., Tarulli, G. A., Hanson, A. R., Ryan, N. K., Pickering, M. A., Birrell, S. N., Hu, D. G., Mackenzie, P. I., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6296 · Cited by 96 · see citing works

Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824

Chen, L., Meng, S., Wang, H., Bali, P., Bai, W., Li, B., Atadja, P. W., Bhalla, K. N., & Wu, J. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-04-0287 · Cited by 96 · see citing works

Frontier of Epilepsy Research - mTOR signaling pathway

Cho, C. (2011) · Experimental & Molecular Medicine · doi:10.3858/emm.2011.43.5.032 · Cited by 92 · see citing works

The status and role of ErbB receptors in human cancer

Überall, I., Kolář, Z., Trojanec, R., Berkovcová, J., & Hajdúch, M. (2008) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2007.12.002 · Cited by 92 · see citing works

A Road Map to Comprehensive Androgen Receptor Axis Targeting for Castration-Resistant Prostate Cancer

Mitsiades, N. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4414 · Cited by 91 · see citing works

Mechanisms of Androgen Receptor Activation in Castration-Resistant Prostate Cancer

Sharifi, N. (2013) · Endocrinology · doi:10.1210/en.2013-1466 · Cited by 91 · see citing works

A phase II study of lapatinib, a dual EGFR and HER-2 tyrosine kinase inhibitor, in patients with castration-resistant prostate cancer

Whang, Y. E., Armstrong, A. J., Rathmell, W. K., Godley, P. A., Kim, W. Y., Pruthi, R. S., Wallen, E., Crane, J. M., Moore, D. T., Grigson, G., et al. (2011) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2010.09.018 · Cited by 89 · see citing works

β4 Integrin signaling induces expansion of prostate tumor progenitors

Yoshioka, T., Otero, J. A., Chen, Y., Kim, Y. M., Koutcher, J. A., Satagopan, J. M., Reuter, V., Carver, B. S., de Stanchina, E., Enomoto, K., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci60720 · Cited by 88 · see citing works

Phase II Study of Androgen Synthesis Inhibition with Ketoconazole, Hydrocortisone, and Dutasteride in Asymptomatic Castration-Resistant Prostate Cancer

Taplin, M., Regan, M. M., Ko, Y., Bubley, G. J., Duggan, S., Werner, L. L., Beer, T. M., Ryan, C. W., Mathew, P. F., Tu, S., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1722 · Cited by 83 · see citing works

Molecular biology of prostate-cancer pathogenesis

Shand, R. L., & Gelmann, E. P. (2006) · Current Opinion in Urology · doi:10.1097/01.mou.0000193384.39351.64 · Cited by 84 · see citing works

Targeting ErbB3: the New RTK(id) on the Prostate Cancer Block

Jathal, M. K., Chen, L., Mudryj, M. M., & Ghosh, P. (2011) · Immunology Endocrine & Metabolic Agents - Medicinal Chemistry · doi:10.2174/187152211795495643 · Cited by 80 · see citing works

Transcriptional network of androgen receptor in prostate cancer progression

Takayama, K., & Inoue, S. (2013) · International Journal of Urology · doi:10.1111/iju.12146 · Cited by 79 · see citing works

Phosphoinositide 3-OH kinase p85α and p110β are essential for androgen receptor transactivation and tumor progression in prostate cancers

Zhu, Q., Youn, H., Tang, J., Tawfik, O. W., Dennis, K. L., Terranova, P. F., Du, J., Raynal, P., Thrasher, J. B., & Li, B. (2008) · Oncogene · doi:10.1038/onc.2008.91 · Cited by 80 · see citing works

Androgen-Dependent Regulation of Her-2/neu in Prostate Cancer Cells

Berger, R., Lin, D. I., Nieto, M., Sicińska, E., Garraway, L. A., Adams, H., Signoretti, S., Hahn, W. C., & Loda, M. F. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3928 · Cited by 79 · see citing works

Minireview: The Molecular and Genomic Basis for Prostate Cancer Health Disparities

Powell, I. J., & Bollig-Fischer, A. B. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1039 · Cited by 76 · see citing works

Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis

Han, H. H., Wang, Y., Curto, J., Gurrapu, S., Laudato, S., Rumandla, A., Chakraborty, G., Wang, X., Chen, H., Jiang, Y., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110595 · Cited by 74 · see citing works

The novel role of pyrvinium in cancer therapy

Momtazi‐borojeni, A. A., Abdollahi, E., Ghasemi, F., Caraglia, M., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26006 · Cited by 75 · see citing works

Androgen Receptor Remains Critical for Cell-Cycle Progression in Androgen-Independent CWR22 Prostate Cancer Cells

Yuan, X., Li, T., Wang, H., Zhang, T., Barua, M., Borgesi, R. A., Bubley, G. J., Lu, M. L., & Balk, S. P. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051047 · Cited by 75 · see citing works

Improving the outcome of patients with castration-resistant prostate cancer through rational drug development

Attard, G., Sarker, D., Reid, A. H. M., Molife, R., Parker, C. C., & Bono, J. S. D. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603223 · Cited by 74 · see citing works

Resistance to Novel Antiandrogen Therapies in Metastatic Castration-Resistant Prostate Cancer

Boudadi, K., & Antonarakis, E. (2016) · Clinical Medicine Insights: Oncology · doi:10.4137/cmo.ss34534 · Cited by 102 · see citing works

Kinases and protein phosphorylation as regulators of steroid hormone action

Weigel, N. L., & Moore, N. L. (2007) · Nuclear Receptor Signaling · doi:10.1621/nrs.05005 · Cited by 72 · see citing works

Adaptive responses of androgen receptor signaling in castration-resistant prostate cancer

Perner, S., Cronauer, M. V., Schrader, A. J., Klocker, H., Čulig, Z., & Baniahmad, A. (2015) · Oncotarget · doi:10.18632/oncotarget.4689 · Cited by 71 · see citing works

Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations

Banneau, G., Guedj, M., MacGrogan, G. M., de Mascarel, I., Velasco, V., Schiappa, R., Bonadona, V., David, A., Dugast, C., Gilbert‐Dussardier, B., et al. (2010) · Breast Cancer Research · doi:10.1186/bcr2626 · Cited by 72 · see citing works

Evolving standards in the treatment of docetaxel-refractory castration-resistant prostate cancer

Antonarakis, E. S., & Armstrong, A. J. (2011) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2011.23 · Cited by 71 · see citing works

Inhibition of HER-2/neu Kinase Impairs Androgen Receptor Recruitment to the Androgen Responsive Enhancer

Liu, Y., Majumder, S., McCall, W., Sartor, C. I., Mohler, J. L., Gregory, C. W., Earp, H. S., & Whang, Y. E. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4292 · Cited by 99 · see citing works

Effect of type I growth factor receptor tyrosine kinase inhibitors on phosphorylation and transactivation activity of the androgen receptor in prostate cancer cells: Ligand-independent activation of the N-terminal domain of the androgen receptor

Sugita, S., Kawashima, H., Tanaka, T., Kurisu, T., Sugimura, K., & Nakatani, T. (2004) · Oncology Reports · doi:10.3892/or.11.6.1273 · Cited by 21 · see citing works

HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.

Wen, Y., Hu, M. C. ‐., Makino, K., Spohn, B., Bartholomeusz, G. A., Yan, D., & Hung, M. (2000) · PubMed · Cited by 461 · see citing works

HER2/HER3 heterodimers in prostate cancer

Freeman, M. R. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.10.018 · Cited by 25 · see citing works

Androgen-Dependent Regulation of Her-2/neu in Prostate Cancer Cells

Berger, R., Lin, D. I., Nieto, M., Sicińska, E., Garraway, L. A., Adams, H., Signoretti, S., Hahn, W. C., & Loda, M. F. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3928 · Cited by 79 · see citing works