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Isolation of two interferon-induced translational inhibitors: a protein kinase and an oligo-isoadenylate synthetase.
Open accessAbstract
Large-scale purification of translational inhibitors present in interferon-treated mouse L cells, but not in untreated cells, led to the isolation of two interferon-induced activities. One is a protein kinase system that is activatable by double-stranded RNA and ATP and that phosphorylates a Mr 67,000 protein and the smallest subunit of eukaryotic initiation factor-2. The purified protein kinase is a strong translational inhibitor. The second activity is an enzyme that, with double-stranded RNA, slowly polymerizes ATP into oligoadenylate with a 2'-5' phosphodiester linkage. The oligo-isoadenylate in turn activates a potent inhibitor of mRNA translation.
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Cited by
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Borden, E. C., Sen, G. C., Uze, G., Silverman, R. H., Ransohoff, R. M., Foster, G. R., & Stark, G. R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2422 · Cited by 1,154
Discriminating self from non-self in nucleic acid sensing
Schlee, M., & Hartmann, G. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.78 · Cited by 593
Terawaki, S., Chikuma, S., Shibayama, S., Hayashi, T., Yoshida, T., Okazaki, T., & Honjo, T. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003208 · Cited by 342
The Oligoadenylate Synthetase Family: An Ancient Protein Family with Multiple Antiviral Activities
Kristiansen, H., Gad, H. H., Eskildsen-Larsen, S., Despres, P., & Hartmann, R. (2011) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0107 · Cited by 310
Hartmann, G. (2017) · Advances in Immunology · doi:10.1016/bs.ai.2016.11.001 · Cited by 285
Metadata
- Authors
- Zilberstein, A., Kimchi, A., Schmidt, A., & Revel, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1978-10
- Volume
- 75
- Issue
- 10
- Pages
- 4734-4738
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2077932788
- Cited by
- 189
- References
- 0
- FWCI
- 13.28
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Isolation of two interferon-induced translational inhibitors: a protein kinase and an oligo-isoadenylate synthetase. https://app.cochat.ai/papers/10.1073/pnas.75.10.4734
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- Zilberstein, A., Kimchi, A., Schmidt, A., & Revel, M. (1978). Isolation of two interferon-induced translational inhibitors: a protein kinase and an oligo-isoadenylate synthetase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.75.10.4734
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