The DOI matches its Crossref record; 167 of the 167 references it cites were found in a registry or an index.
Discriminating self from non-self in nucleic acid sensing
Open accessAbstract
Innate immunity against pathogens relies on an array of immune receptors to detect molecular patterns that are characteristic of the pathogens, including receptors that are specialized in the detection of foreign nucleic acids. In vertebrates, nucleic acid sensing is the dominant antiviral defence pathway. Stimulation of nucleic acid receptors results in antiviral immune responses with the production of type I interferon (IFN), as well as the expression of IFN-stimulated genes, which encode molecules such as cell-autonomous antiviral effector proteins. This Review summarizes the tremendous progress that has been made in understanding how this sophisticated immune sensory system discriminates self from non-self nucleic acids in order to reliably detect pathogenic viruses.
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2 retracted
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Cited by
The biogenesis, biology and characterization of circular RNAs
Kristensen, L. S., Andersen, M. S., Stagsted, L. V. W., Ebbesen, K. K., Hansen, T. B., & Kjems, J. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0158-7 · Cited by 4,823
Mitochondrial double-stranded RNA triggers antiviral signalling in humans
Dhir, A., Dhir, S., Borowski, L. S., Jimenez, L., Teitell, M., Rötig, A., Crow, Y. J., Rice, G. I., Duffy, D., Tamby, C., et al. (2018) · Nature · doi:10.1038/s41586-018-0363-0 · Cited by 631
Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies
Patel, S. A., & Minn, A. J. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.007 · Cited by 573
Nabet, B. Y., Qiu, Y., Shabason, J. E., Wu, T. J., Yoon, T., Kim, B. C., Benci, J. L., DeMichele, A. M., Tchou, J., Marcotrigiano, J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.031 · Cited by 452
Zheng, Q., Hou, J., Zhou, Y., Li, Z., & Cao, X. (2017) · Nature Immunology · doi:10.1038/ni.3830 · Cited by 367
Metadata
- Authors
- Schlee, M., & Hartmann, G.
- Venue
- Nature Reviews Immunology
- Published
- 2016-07-25
- Volume
- 16
- Issue
- 9
- Pages
- 566-580
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2494587789
- Cited by
- 593
- References
- 167
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schlee, M., & Hartmann, G. (2016). Discriminating self from non-self in nucleic acid sensing. Nature Reviews Immunology. https://doi.org/10.1038/nri.2016.78
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