The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Model for evolution of Y chromosomes and dosage compensation.
Open accessAbstract
Some difficulties with the classical model for the evolution of a genetically invert Y chromosome are discussed. An alternative model is proposed, which is based on the principle of Mullers ratchet; this involves the accumulation of chromosomes bearing deleterious mutant genes in a finite population in the absence of crossing-over. This process would result in the gradual increase, with time, in the number of mutant loci carried in an average Y chromosome, although the frequency of individual deleterious alleles at most loci remains low. It is shown that this creates a selection pressure for differentially increasing the activity of the X chromosome in heterogametic individuals at the expense of that of the Y, leading eventually to a genetically inert Y chromosome and to the evolution of dosage compensation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hamilton, W. D. (1967) · Science · doi:10.1126/science.156.3774.477 · Cited by 3,626
The relation of recombination to mutational advance
Muller, H. J. (1964) · Mutation Research · doi:10.1016/0027-5107(64)90047-8 · Cited by 2,512
THE EVOLUTIONARY ADVANTAGE OF RECOMBINATION
Felsenstein, J. (1974) · Genetics · doi:10.1093/genetics/78.2.737 · Cited by 1,711
Muller, H. J. (1950) · Europe PMC (PubMed Central) · Cited by 753
Mutations affecting fitness in Drosophila populations.
Simmons, M. J., & Crow, J. F. (1977) · Annual Review of Genetics · doi:10.1146/annurev.ge.11.120177.000405 · Cited by 584
The Role of X-Chromosome Inactivation during Spermatogenesis
Lifschytz, E., & Lindsley, D. L. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.1.182 · Cited by 498
MUTATION RATE AND DOMINANCE OF GENES AFFECTING VIABILITY IN DROSOPHILA MELANOGASTER
Mukai, T., Chigusa, S. I., Mettler, L. E., & Crow, J. F. (1972) · Genetics · doi:10.1093/genetics/72.2.335 · Cited by 488
GENETIC VARIABILITY, TWIN HYBRIDS AND CONSTANT HYBRIDS, IN A CASE OF BALANCED LETHAL FACTORS
Muller, H. J. (1918) · Genetics · doi:10.1093/genetics/3.5.422 · Cited by 336
MUKHERJEE, A. S., & BEERMANN, W. (1965) · Nature · doi:10.1038/207785a0 · Cited by 198
COOPER, D. W., VANDEBERG, J. L., SHARMAN, G. B., & POOLE, W. E. (1971) · Nature New Biology · doi:10.1038/newbio230155a0 · Cited by 182
Cited by
SEXUAL DIMORPHISM, SEXUAL SELECTION, AND ADAPTATION IN POLYGENIC CHARACTERS
Lande, R. (1980) · Evolution · doi:10.1111/j.1558-5646.1980.tb04817.x · Cited by 1,878
The evolution of gene expression levels in mammalian organs
Brawand, D., Soumillon, M., Necsulea, A., Julien, P., Csárdi, G., Harrigan, P., Weier, M., Liechti, A., Aximu-Petri, A., Kircher, M., et al. (2011) · Nature · doi:10.1038/nature10532 · Cited by 1,248
X chromosomal abnormalities in basal-like human breast cancer
Richardson, A. L., Wang, Z. C., De Nicolo, A., Lu, X., Brown, M., Miron, A., Liao, X., Iglehart, J. D., Livingston, D. M., & Ganesan, S. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.01.013 · Cited by 869
Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration
Bachtrog, D. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3366 · Cited by 854
Origins and functional evolution of Y chromosomes across mammals
Cortez, D., Marin, R., Toledo-Flores, D., Froidevaux, L., Liechti, A., Waters, P. D., Grützner, F., & Kaessmann, H. (2014) · Nature · doi:10.1038/nature13151 · Cited by 532
Metadata
- Authors
- Charlesworth, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1978-11
- Volume
- 75
- Issue
- 11
- Pages
- 5618-5622
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2058555694
- Cited by
- 408
- References
- 15
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Model for evolution of Y chromosomes and dosage compensation. https://app.cochat.ai/papers/10.1073/pnas.75.11.5618
- The paper
- Charlesworth, B. (1978). Model for evolution of Y chromosomes and dosage compensation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.75.11.5618
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
