The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Intragenic DNA spacers interrupt the ovalbumin gene
Open accessAbstract
We have performed restriction endonuclease mapping to examine the linear organization of the ovalbumin gene in chromosomal DNA. Treatment of genomic DNA with restriction endonucleases that do not cleave the ovalbumin mRNA sequence results in the generation of multiple DNA fragments capable of annealing with ovalbumin-specific probes in molecular hybridization reactions. These data strongly suggest that the linear order of DNA sequences coding for ovalbumin is interrupted by at least two intragenic DNA spacers absent from the corresponding RNA. At least one of these spacer sequences interrupts the coding sequence; therefore the chromosomal ovalbumin gene is not colinear with its translational product. We can discern no difference in the sequence organization about this gene in producer and nonproducer somatic cells, suggesting that the presence of intragenic spacers does not reflect that transcriptional activity of this gene. Furthermore, profiles obtained for gametes are identical to those observed for somatic cells, indicating that significant translocation during development is not responsible for the generation of this split sequence. Divergence of the intragenic spacer, however, is observed between individual chickens; thus multiple alleles may exist for this gene that are identifiable by differences in the organization of spacer with no apparent phenotypic evidence for their presence.
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Cites
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Self-citationSelective digestion of transcriptionally active ovalbumin genes from oviduct nuclei.
Garel, A., & Axel, R. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.3966 · Cited by 512
Self-citationThe rabbit β-globin gene contains a large insert in the coding sequence
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Ovalbumin gene is split in chicken DNA
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Noda, M., Furutani, Y., Takahashi, H., Toyosato, M., Tanabe, T., Shimizu, S., Kikyotani, S., Kayano, T., Hirose, T., Inayama, S., et al. (1983) · Nature · doi:10.1038/305818a0 · Cited by 431
Isolation and sequence analysis of the human corticotropin-releasing factor precursor gene.
Shibahara, S., Morimoto, Y., Furutani, Y., Notake, M., Takahashi, H., Shimizu, S., Horikawa, S., & Numa, S. (1983) · The EMBO Journal · doi:10.1002/j.1460-2075.1983.tb01499.x · Cited by 422
Primary structure of the α-subunit of transducin and its relationship to ras proteins
Tanabe, T., Nukada, T., Nishikawa, Y., Sugimoto, K., Suzuki, H., Takahashi, H., Noda, M., Haga, T., Ichiyama, A., Kangawa, K., et al. (1985) · Nature · doi:10.1038/315242a0 · Cited by 287
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Metadata
- Authors
- Weinstock, R., Sweet, R., Weiss, M., Cedar, H., & Axel, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1978-03
- Volume
- 75
- Issue
- 3
- Pages
- 1299-1303
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2042357352
- Cited by
- 277
- References
- 18
- FWCI
- 16.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Weinstock, R., Sweet, R., Weiss, M., Cedar, H., & Axel, R. (1978). Intragenic DNA spacers interrupt the ovalbumin gene. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.75.3.1299
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