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Neurons containing beta-endorphin in rat brain exist separately from those containing enkephalin: immunocytochemical studies.
Open accessAbstract
Well-characterized antisera to porcine beta-endorphin were used to localize immunoreactive sites in cryostat sections of formaldehyde-fixed rat brain by indirect immunohistochemistry. Specificity was established by absorption of immune sera with synthetic peptide fragments. Specific immunoreactivity was localized to neuronal perikarya in the basal tuberal hypothalamus, and to varicose nerve fibers which were distributed to midline nuclear areas throughout the diencephalon and anterior pons. These patterns of reactivity were unaffected by preabsorption of the immune sera with millimolar concentrations of Met5- or Leu5-enkephalin or alpha-endorphin. The beta-endorphin immunoreactive structures were morphologically separate from those cells and fibers reported to react with antisera to the enkephalins. One anti-beta-endorphin serum gave additional immunoreactivity with myelinated axons in limbic cortical zones; when absorbed with purified rat myelin basic protein, only the specific patterns of immunoreactivity remained. Thus, discrete beta-endorphin-containing neuronal circuits exist in rat brain and are anatomically distinguishable from enkephalin-containing nerve cell and fiber pathways.
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Citations
Cited by
Nucleus locus ceruleus: new evidence of anatomical and physiological specificity
Foote, S. L., Bloom, F. E., & Aston-Jones, G. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.3.844 · Cited by 1,901
Self-citationBen-Ari, Y., Tremblay, E., Riche, D., Ghilini, G., & Naquet, R. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90193-7 · Cited by 649
Zieglgänsberger, W., French, E. D., Siggins, G. R., & Bloom, F. E. (1979) · Science · doi:10.1126/science.451610 · Cited by 607
Self-citationThe immunocytochemical localization of enkephalin in the central nervous system of the rat
Finley, J. C. W., Maderdrut, J. L., & Petrusz, P. (1981) · Journal of Comparative Neurology · doi:10.1002/cne.901980402 · Cited by 554
Autoregulation of Serotonin Neurons: Role in Antidepressant Drug Action
Piñeyro, G., & Blier, P. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01417-0 · Cited by 537
Metadata
- Authors
- Bloom, F., Battenberg, E., Rossier, J., Ling, N., & Guillemin, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1978-03
- Volume
- 75
- Issue
- 3
- Pages
- 1591-1595
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2039946713
- Cited by
- 653
- References
- 0
- FWCI
- 24.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Bloom, F., Battenberg, E., Rossier, J., Ling, N., & Guillemin, R. (1978). Neurons containing beta-endorphin in rat brain exist separately from those containing enkephalin: immunocytochemical studies. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.75.3.1591
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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