The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Opioid Peptides May Excite Hippocampal Pyramidal Neurons by Inhibiting Adjacent Inhibitory Interneurons
Abstract
The atypical excitation by opiates and opioid peptides of hippocampal pyramidal cells can be antagonized by iontophoresis of naloxone, the γ-aminobutyric acid antagonist bicuculline, or magnesium ion. The recurrent inhibition of these cells evoked by transcallosal stimulation of the contralateral hippocampus is blocked by enkephalin but only shortened by acetylcholine. The results suggest that the opioids excite pyramidal neurons indirectly by inhibition of neighboring inhibitory interneurons (probably containing γ-aminobutyric acid). This mechanism may be pertinent to the electrographic signs of addictive drugs.
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Citations
Cites
Bloom, F., Battenberg, E., Rossier, J., Ling, N., & Guillemin, R. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.3.1591 · Cited by 653
Self-citationRibak, C. E., Vaughn, J. E., & Saito, K. (1978) · Brain Research · doi:10.1016/0006-8993(78)90463-8 · Cited by 627
GABA, Bicuculline and Central Inhibition
CURTIS, D. R., DUGGAN, A. W., FELIX, D., & JOHNSTON, G. A. R. (1970) · Nature · doi:10.1038/2261222a0 · Cited by 540
Regional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary.
Rossier, J., Vargo, T. M., Minick, S., Ling, N., Bloom, F. E., & Guillemin, R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.11.5162 · Cited by 452
Self-citationAspartate and glutamate as possible transmitters of excitatory hippocampal afferents
NADLER, J. V., VACA, K. W., WHITE, W. F., LYNCH, G. S., & COTMAN, C. W. (1976) · Nature · doi:10.1038/260538a0 · Cited by 302
Determination of methionine enkephalin in discrete regions of rat brain
Hong, J. S., Yang, H.-Y. T., Fratta, W., & Costa, E. (1977) · Brain Research · doi:10.1016/0006-8993(77)91084-8 · Cited by 281
Frederickson, R. C. A. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90421-0 · Cited by 269
Simon, E. J., & Hiller, J. M. (1978) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.18.040178.002103 · Cited by 267
Micromethods in Neurophannacology
SALMOIRAGHI, G. C., & WEIGHT, F. (1967) · Anesthesiology · doi:10.1097/00000542-196701000-00007 · Cited by 242
beta-Endorphin induces nonconvulsive limbic seizures.
Henriksen, S. J., Bloom, F. E., McCoy, F., Ling, N., & Guillemin, R. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.10.5221 · Cited by 191
Self-citation
Cited by
Gray, J. A. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00013066 · Cited by 4,477
Interneurons of the hippocampus
Freund, T. F., & Buzsáki, G. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:4<347::aid-hipo1>3.0.co;2-i · Cited by 3,441
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
Self-citationCalbindin D-28k and parvalbumin in the rat nervous system
Celio, M. R. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90091-h · Cited by 2,078
Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning
Buzsáki, G. (2015) · Hippocampus · doi:10.1002/hipo.22488 · Cited by 1,759
Metadata
- Authors
- Zieglgänsberger, W., French, E. D., Siggins, G. R., & Bloom, F. E.
- Venue
- Science
- Published
- 1979-07-27
- Volume
- 205
- Issue
- 4404
- Pages
- 415-417
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2094787900
- Cited by
- 607
- References
- 20
- FWCI
- 19.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Opioid Peptides May Excite Hippocampal Pyramidal Neurons by Inhibiting Adjacent Inhibitory Interneurons. https://app.cochat.ai/papers/10.1126/science.451610
- The paper
- Zieglgänsberger, W., French, E. D., Siggins, G. R., & Bloom, F. E. (1979). Opioid Peptides May Excite Hippocampal Pyramidal Neurons by Inhibiting Adjacent Inhibitory Interneurons. Science. https://doi.org/10.1126/science.451610
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
