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Cited by 1,105

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Protein kinase activity associated with the avian sarcoma virus src gene product.

Open access
Collett, M S, Erikson, R L·1978·Proceedings of the National Academy of Sciences

Abstract

Incorporation of phosphorus from [gamma-32P]ATP into protein was catalyzed by specific immunoprecipitates from avian sarcoma virus (ASV)-transformed avian and mammalian cells. This incorporation was observed only when antiserum from tumor-bearing rabbits able to specifically precipitate the ASV sarcoma gene product, p60src, was used to immunoprecipitate antigens from transformed cell lysates. Immunoprecipitates of extracts from normal cells or cells infected with a transformation-defective ASV mutant showed no activity in this assay, nor did any immune complexes formed with normal rabbit serum and any of the cell extracts tested. The expression of the protein kinase activity (ATP:protein phosphotransferase, EC 2.7.1.37) was growth temperature-dependent in cells infected with an ASV mutant temperature-sensitive for the transformation. These results on an enzymatic activity associated with the ASV transforming protein are discussed in terms of protein phosphorylation as a mechanism for viral transformation.

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Metadata

Authors
Collett, M. S., & Erikson, R. L.
Venue
Proceedings of the National Academy of Sciences
Published
1978-04
Volume
75
Issue
4
Pages
2021-2024
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2064529356
Cited by
1,105
References
1
FWCI
50.17
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Protein kinase activity associated with the avian sarcoma virus src gene product. https://app.cochat.ai/papers/10.1073/pnas.75.4.2021
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Collett, M. S., & Erikson, R. L. (1978). Protein kinase activity associated with the avian sarcoma virus src gene product. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.75.4.2021

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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