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Diabetic cataract formation: potential role of glycosylation of lens crystallins.
Open accessAbstract
A high glucose concentration in vivo or an increased glucose of glucose 6-phosphate concentration in vitro has been found to lead to the glycosylation of epsilon-amino groups of lysine residues in bovine and rat lens crystallins. In vitro, this glycosylation imparts an increased susceptibility of the crystallins to sulfhydryl oxidation. Disulfide crosslinks result in the formation of high molecular weight aggregates and an opalescence in the crystallin solutions. The addition of reducing agents prevents as well as reverses the formation of high molecular weight aggregates and the opalescence of the crystallins. These phenomena suggest a new interpretation of previous results on cataract formation and a new approach for development of drugs to prevent cataracts.
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Citations
Cited by
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Bunn, H. F., & Higgins, P. J. (1981) · Science · doi:10.1126/science.12192669 · Cited by 598
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Advanced Glycosylation: Chemistry, Biology, and Implications for Diabetes and Aging
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Self-citationFructosamine: structure, analysis, and clinical usefulness.
Armbruster, D. A. (1987) · Clinical Chemistry · doi:10.1093/clinchem/33.12.2153 · Cited by 437
Metadata
- Authors
- Stevens, V. J., Rouzer, C. A., Monnier, V. M., & Cerami, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1978-06
- Volume
- 75
- Issue
- 6
- Pages
- 2918-2922
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2016591133
- Cited by
- 412
- References
- 0
- FWCI
- 8.06
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Diabetic cataract formation: potential role of glycosylation of lens crystallins. https://app.cochat.ai/papers/10.1073/pnas.75.6.2918
- The paper
- Stevens, V. J., Rouzer, C. A., Monnier, V. M., & Cerami, A. (1978). Diabetic cataract formation: potential role of glycosylation of lens crystallins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.75.6.2918
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
