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Nerve growth factor-induced fiber outgrowth from isolated rat adrenal chromaffin cells: impairment by glucocorticoids.
Open accessAbstract
Addition of nerve growth factor to cultures of dissociated rat adrenal medullary cells caused fiber outgrowth from chromaffin cells. These fibers exhibited all the characteristics of neurites, particularly the formation of typical growth cones exhibiting intense catecholamine-specific fluorescence. Because this nerve growth factor-mediated neurite outgrowth could be abolished by physiological concentrations of glucocorticoids, it is concluded that the high glucocorticoid concentrations normally present in the adrenal medulla prevent the fiber outgrowth from medullary chromaffin cells in vivo. In dissociated sympathetic neurons the same concentrations of glucocorticoids markedly reduce but do not completely abolish neuronal fiber outgrowth.
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Cited by
Anderson, D. J., & Axel, R. (1986) · Cell · doi:10.1016/0092-8674(86)90823-8 · Cited by 339
Roles of steroid hormones and their receptors in structural organization in the nervous system
Kawata, M. (1995) · Neuroscience Research · doi:10.1016/0168-0102(96)81278-8 · Cited by 332
Signals and switches in mammalian neural crest cell differentiation
Bhatt, S., Diaz, R., & Trainor, P. A. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008326 · Cited by 200
Matsuoka, H., Harada, K., Nakamura, J., & Inoue, M. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1222-3 · Cited by 19
Metadata
- Authors
- Unsicker, K., Krisch, B., Otten, U., & Thoenen, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1978-07
- Volume
- 75
- Issue
- 7
- Pages
- 3498-3502
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2011035028
- Cited by
- 461
- References
- 0
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Nerve growth factor-induced fiber outgrowth from isolated rat adrenal chromaffin cells: impairment by glucocorticoids. https://app.cochat.ai/papers/10.1073/pnas.75.7.3498
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- Unsicker, K., Krisch, B., Otten, U., & Thoenen, H. (1978). Nerve growth factor-induced fiber outgrowth from isolated rat adrenal chromaffin cells: impairment by glucocorticoids. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.75.7.3498
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
