The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Ribonuclease P: an enzyme with an essential RNA component.
Open accessAbstract
The activity of ribonuclease P on precursor tRNA substrates from Escherichia coli can be abolished by pretreatment of this enzyme with micrococcal nuclease or pancreatic ribonuclease A, as well as by proteases and by thermal denaturation. Highly purified RNase P exhibits one prominent RNA and one prominent polypeptide component when examined in polyacrylamide gels containing sodium dodecyl sulfate. The buoyant density in CsCl of RNase P, 1.71 g/ml, is characteristic of a protein-RNA complex. The activity of RNase P is inhibited by various RNA molecules. The presence of a discrete RNA component in RNase P appears to be essential for enzymatic function. A model is described for enzyme-substrate recognition in which this RNA component plays an important role.
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Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane
Fairbanks, G., Steck, T. L., & Wallach, D. F. H. (1971) · Biochemistry · doi:10.1021/bi00789a030 · Cited by 8,526
Resolution of Multiple Ribonucleic Acid Species by Polyacrylamide Gel Electrophoresis*
Peacock, A. C., & Dingman, C. W. (1967) · Biochemistry · doi:10.1021/bi00858a033 · Cited by 860
Steitz, J. A., & Jakes, K. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.12.4734 · Cited by 691
Transfer RNA: Molecular Structure, Sequence, and Properties
Rich, A., & RajBhandary, U. L. (1976) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.45.070176.004105 · Cited by 650
Purification and Properties of Ribonuclease III from Escherichia coli
Robertson, H. D., Webster, R. E., & Zinder, N. D. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99327-0 · Cited by 478
Three-Dimensional Structure of Yeast Phenylalanine Transfer RNA: Folding of the Polynucleotide Chain
Kim, S. H., Quigley, G. J., Suddath, F. L., McPherson, A., Sneden, D., Kim, J. J., Weinzierl, J., & Rich, A. (1973) · Science · doi:10.1126/science.179.4070.285 · Cited by 421
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Self-citationSmall Ribonucleic Acids of Escherichia coli
Ikemura, T., & Dahlberg, J. E. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43666-1 · Cited by 301
Structure of yeast phenylalanine transfer RNA at 2.5 A resolution.
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Cited by
The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N., & Altman, S. (1983) · Cell · doi:10.1016/0092-8674(83)90117-4 · Cited by 2,684
Self-citationRibosome Profiling Provides Evidence that Large Noncoding RNAs Do Not Encode Proteins
Guttman, M., Russell, P., Ingolia, N. T., Weissman, J. S., & Lander, E. S. (2013) · Cell · doi:10.1016/j.cell.2013.06.009 · Cited by 745
Targeting RNA structures with small molecules
Childs-Disney, J. L., Yang, X., Gibaut, Q. M. R., Tong, Y., Batey, R. T., & Disney, M. D. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00521-4 · Cited by 587
Jonikas, M. A., Radmer, R. J., Laederach, A., Das, R., Pearlman, S., Herschlag, D., & Altman, R. B. (2009) · RNA · doi:10.1261/rna.1270809 · Cited by 316
Metadata
- Authors
- Stark, B. C., Kole, R., Bowman, E. J., & Altman, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1978-08
- Volume
- 75
- Issue
- 8
- Pages
- 3717-3721
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1999608841
- Cited by
- 301
- References
- 15
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stark, B. C., Kole, R., Bowman, E. J., & Altman, S. (1978). Ribonuclease P: an enzyme with an essential RNA component. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.75.8.3717
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
