The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration.
Open accessAbstract
Sensory neurons grown in dispersed cell culture in the absence of non-neuronal cell types contain immunoreactive substance P that is chemically similar to synthetic substance P. When depolarized in high-K+ media (30-120 mM), the neurons release this peptide by a Ca2+-dependent mechanism. An enkephalin analogue, [D-Ala2]enkephalin amide, at 10 micron inhibits the K+-evoked release of substance P. At the same or lower concentrations, [D-Ala2]enkephalin amide and enkephalin decrease the duration of the Ca2+ action potential evoked and recorded in dorsal root ganglion cell bodies without affecting the resting membrane potential or resting membrane conductance. This modulation of voltage-sensitive channels may account for the inhibition of substance P release.
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Cites
Endogenous opioid peptides: multiple agonists and receptors
Lord, J. A. H., Waterfield, A. A., Hughes, J., & Kosterlitz, H. W. (1977) · Nature · doi:10.1038/267495a0 · Cited by 2,485
Cited by
Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry
Basbaum, A. I., & Fields, H. L. (1984) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.07.030184.001521 · Cited by 2,687
Gibbins, I. L., Furness, J. B., & Costa, M. (1987) · Cell and Tissue Research · doi:10.1007/bf00218210 · Cited by 351
Tsunoo, A., Yoshii, M., & Narahashi, T. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9832 · Cited by 218
Walters, E. T. (1994) · International Review of Neurobiology · doi:10.1016/s0074-7742(08)60307-4 · Cited by 206
Metadata
- Authors
- Mudge, A. W., Leeman, S. E., & Fischbach, G. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1979-01
- Volume
- 76
- Issue
- 1
- Pages
- 526-530
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2057288321
- Cited by
- 547
- References
- 1
- FWCI
- 19.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Mudge, A. W., Leeman, S. E., & Fischbach, G. D. (1979). Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.76.1.526
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