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Purification of two spectrin-binding proteins: biochemical and electron microscopic evidence for site-specific reassociation between spectrin and bands 2.1 and 4.1.
Open accessAbstract
Two peripheral proteins of the human erythrocyte membrane that are capable of forming a stable complex with spectrin have been purified. The proteins, band 2.1 (Mr 210,000) and band 4.1 (Mr 82,000), are water soluble and exist as monomers in solution. Both exhibit strong, specific binding to purified spectrin molecules as determined by cosedimentation in sucrose gradients and both enhance binding to spectrin-depleted, inside-out vesicles that have been stripped of bands 2.1 and 4.1. Rotary replicas of bound material reveal site-specific associations among native, but not heat-denatured, molecules.
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Citations
Cited by
The Spectrin-Based Membrane Skeleton and Micron-Scale Organization of the Plasma Membrane
Bennett, V., & Gilligan, D. M. (1993) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.09.110193.000331 · Cited by 466
Erythrocyte spectrin is comprised of many homologous triple helical segments
Speicher, D. W., & Marchesi, V. T. (1984) · Nature · doi:10.1038/311177a0 · Cited by 417
Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites
Hayashi, T., Rumbaugh, G., & Huganir, R. L. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.035 · Cited by 287
Conboy, J., Kan, Y. W., Shohet, S. B., & Mohandas, N. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9512 · Cited by 105
Metadata
- Authors
- Tyler, J. M., Hargreaves, W. R., & Branton, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1979-10
- Volume
- 76
- Issue
- 10
- Pages
- 5192-5196
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2010621566
- Cited by
- 281
- References
- 0
- FWCI
- 21.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Purification of two spectrin-binding proteins: biochemical and electron microscopic evidence for site-specific reassociation between spectrin and bands 2.1 and 4.1. https://app.cochat.ai/papers/10.1073/pnas.76.10.5192
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- Tyler, J. M., Hargreaves, W. R., & Branton, D. (1979). Purification of two spectrin-binding proteins: biochemical and electron microscopic evidence for site-specific reassociation between spectrin and bands 2.1 and 4.1. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.76.10.5192
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
