Cited by 883Neuropeptides and Animal PhysiologyNeuroendocrine regulation and behaviorChemical Synthesis and Analysis

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Dynorphin-(1-13), an extraordinarily potent opioid peptide.

Open access

Goldstein, A, Tachibana, S, Lowney, L I, Hunkapiller, M, Hood, L·1979·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.76.12.6666PMC PMC411929

Open this paper in CoChat — free account

Abstract

We describe the opioid properties of a tridecapeptide, the sequence of which corresponds to the NH2-terminal sequence of dynorphin, a novel porcine pituitary endorphin. It contains [Leu]enkephalin. In the guinea pig ileum longitudinal muscle preparation it is about 700 times more potent than [Leu]enkephalin. Its effects in this tissue are blocked completely by naloxone, but the apparent affinity of naloxone is 1/13th that for blockade of [Leu]enkephalin or normorphine. In the mouse vas deferens, this peptide is 3 times more potent than [Leu]enkephalin. Well-washed rat brain membranes degrade the peptide rapidly, suggesting the presence of a membrane-bound degradative enzyme. The peptide displays considerable immunoreactivity in assays with antisera that have been used for the immunohistochemical localization of [Leu]enkephalin. The remarkable enhancement of the potency of [Leu]enkephalin by the COOH-terminal extension -Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH suggests new interpretations concerning the structure of opiate receptors and the function of the enkephalin pentapeptides.

Integrity signals

Registry

Crossref · 10.1073/pnas.76.12.6666

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity
Hunter, W. M., & Greenwood, F. C. (1962) · Nature · doi:10.1038/194495a0 · Cited by 6,902
Endogenous opioid peptides: multiple agonists and receptors
Lord, J. A. H., Waterfield, A. A., Hughes, J., & Kosterlitz, H. W. (1977) · Nature · doi:10.1038/267495a0 · Cited by 2,485
Purification and properties
Cox, B. M., Opheim, K. E., Teschemacher, H., & D, A. G. M. (1975) · Life Sciences · doi:10.1016/0024-3205(75)90272-6 · Cited by 1,708
Immunohistochemical localization of enkephalin in rat brain and spinal cord
Sar, M., Stumpf, W. E., Miller, R. J., Chang, K., & Cuatrecasas, P. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901820103 · Cited by 822
Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity.
Chang, K. J., & Cuatrecasas, P. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30115-1 · Cited by 683
[D-Ala 2 ]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide Analgesic
Pert, C. B., Pert, A., Chang, J., & Fong, B. T. W. (1976) · Science · doi:10.1126/science.968485 · Cited by 469
Endogenous and Exogenous Opiate Agonists and Antagonists
(1980) · Elsevier eBooks · doi:10.1016/c2013-0-03337-3 · Cited by 447
EFFECT OF MORPHINE ON ADRENERGIC TRANSMISSION IN THE MOUSE VAS DEFERENS. ASSESSMENT OF AGONIST AND ANTAGONIST POTENCIES OF NARCOTIC ANALGESICS
Hughes, J. W., Kosterlitz, H. W., & Leslie, F. M. (1975) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1975.tb07373.x · Cited by 405
Direct microsequence analysis of polypeptides using an improved sequenator, a nonprotein carrier (Polybrene), and high pressure liquid chromatography
Hunkapiller, M. W., & Hood, L. (1978) · Biochemistry · doi:10.1021/bi00604a016 · Cited by 383
Self-citation
In Vitro Models in the Study of Structure-Activity Relationships of Narcotic Analgesics
Kosterlitz, H. W., & Waterfield, A. A. (1975) · Annual Review of Pharmacology · doi:10.1146/annurev.pa.15.040175.000333 · Cited by 293

Show all 18 references

Sorted by citations

Items 101–200 of 883

NALOXONE, A SPECIFIC OPIOID ANTAGONIST, REVERSES CHRONIC IDIOPATHIC CONSTIPATION
Kreek, M.-J., Hahn, E. F., Schaefer, R., & Fishman, J. (1983) · The Lancet · doi:10.1016/s0140-6736(83)91684-7 · Cited by 133
The distribution of proenkephalin‐derived peptides in the central nervous system of turtles
Reiner, A. J. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902590106 · Cited by 126
The Opioid Peptide Dynorphin, Circadian Rhythms, and Starvation
Przewłocki, R., Lasoń, W., Konecka, A. M., Gramsch, C., Herz, A., & Reid, L. D. (1983) · Science · doi:10.1126/science.6129699 · Cited by 126
Immunoreactive Dynorphin-(1-8) and Corticotropin-Releasing Factor in Subpopulation of Hypothalamic Neurons
Roth, K. A., Weber, E., Barchas, J. D., Chang, D., & Chang, J. (1983) · Science · doi:10.1126/science.6129700 · Cited by 124
Two adrenal opioid polypeptides: proposed intermediates in the processing of proenkephalin.
STERN, A. S., Jones, B. N., Shively, J. E., Stein, S., & Undenfriend, S. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.3.1962 · Cited by 124
Immunohistochemical distribution of dynorphin B in rat brain: relation to dynorphin A and alpha-neo-endorphin systems.
Weber, E., & Barchas, J. D. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.4.1125 · Cited by 123
Enkephalin‐mediated basal ganglia influences over the optic tectum: Immunohistochemistry of the tectum and the lateral spiriform nucleus in pigeon
Reiner, A. J., Karten, H. J., & Brecha, N. C. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902080104 · Cited by 121
Distribution of mu, delta, and kappa opiate receptor types in the forebrain and midbrain of pigeons
Reiner, A. J., Brauth, S. E., Kitt, C. A., & Quirion, R. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902800304 · Cited by 119
Pharmacology Of Dynorphin
Smith, A. P., & Lee, N. M. (1988) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.28.040188.001011 · Cited by 119
β-Endorphin and drug-induced reward and reinforcement
Roth‐Deri, I., Green-Sadan, T., & Yadid, G. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.06.003 · Cited by 126
Endogenous opioid peptides: review of physiological, pharmacological and clinical aspects
Frederickson, R. C. A., & Geary, L. E. (1982) · Progress in Neurobiology · doi:10.1016/0301-0082(82)90020-x · Cited by 116
Opioids and their receptors: Are we there yet?
Pasternak, G. W. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.039 · Cited by 115
“The enkephalins were soon followed by the isolation of dynorphin A (Goldstein et al., 1979) and β-endorphin (Li et al., 1976).”
Background
Endorphins and food intake: Kappa opioid receptor agonists and hyperphagia
Cooper, S. J., Jackson, A. E., & Kirkham, T. C. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90088-7 · Cited by 115
Dynorphin-(1–13), dopamine and feeding in rats
Morley, J. E., Levine, A. S., Grace, M. K., & Kneip, J. M. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90221-0 · Cited by 113
Dynorphin/kappa-opioid receptor control of dopamine dynamics: Implications for negative affective states and psychiatric disorders
Tejeda, H. A., & Bonci, A. (2018) · Brain Research · doi:10.1016/j.brainres.2018.09.023 · Cited by 117
Opioid receptors and endogenous opioid peptides
Simon, E. J. (1991) · Medicinal Research Reviews · doi:10.1002/med.2610110402 · Cited by 111
Dynorphin interaction at the κ-opiate site
Huidobro-Toro, J. P., Yoshimura, K., Lee, N. M., Loh, H. H., & Way, E. L. (1981) · European Journal of Pharmacology · doi:10.1016/0014-2999(81)90284-3 · Cited by 112
Neuropeptides in epilepsy
Kovac, S., & Walker, M. C. (2013) · Neuropeptides · doi:10.1016/j.npep.2013.10.015 · Cited by 116
Striato-nigral dynorphin and substance P pathways in the rat
Herrera‐Marschitz, M., Christensson-Nylander, I., Sharp, T., Staines, W. A., Reid, M. S., H�kfelt, T., Terenius, L. Y., & Ungerstedt, U. (1986) · Experimental Brain Research · doi:10.1007/bf00238214 · Cited by 110
“The peptides DYN A, DYN B, ~-neoendorphin and ~-neoendorphin ( Goldstein et al. 1979, 1981; Tachibana et al. 1982) are present in high concentrations in the substantia nigra of several species, as compared to other brain structures (Gramsch et al. 1982; Maysinger et al. 1982; Zamir et al. 1983; Pittius et al. 1984; Za…”
Background
Irreversible Ligands with High Selectivity Toward δ and μ Opiate Receptors
Rice, K. C., Jacobson, A. E., Burke, T. R., Bajwa, B. S., Streaty, R. A., & Klee, W. A. (1983) · Science · doi:10.1126/science.6132444 · Cited by 109
Parallel distribution of immunoreactive α-neo-endorphin and dynorphin in rat and human tissue
Maysinger, D., Höllt, V., Seizinger, B. R., Mehraein, P., Pasi, A., & Herz, A. (1982) · Neuropeptides · doi:10.1016/0143-4179(82)90054-3 · Cited by 108
Distribution of immunoreactive dynorphin in the central nervous system of the rat
Zamir, N., Palkovits, M., & Brownstein, M. (1983) · Brain Research · doi:10.1016/0006-8993(83)91176-9 · Cited by 110
Novel d-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral κ-opioid receptors,
Vanderah, T. W., Largent‐Milnes, T. M., Lai, J. Y., Porreca, F., Houghten, R. A., Menzaghi, F., Wiśniewski, K., Stalewski, J., Sueiras-Diaz, J., Galyean, R., et al. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.011 · Cited by 104
Central Neurotransmitters and Acupuncture Analgesia
Han, J.-S., Tang, J., Ren, M. F., Zhou, Z., Fan, S. G., & Qiu, X. C. (1980) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x80000311 · Cited by 104
Comparison of met‐enkephalin‐, dynorphin A‐, and neurotensin‐immunoreactive neurons in the cat and rat spinal cords: I. Lumbar cord
Miller, K. E., & Seybold, V. S. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902550212 · Cited by 104
Experimental endotoxin shock: the pathophysiologic function of endorphins and treatment with opiate antagonists.
Faden, A. I., & Holaday, J. (1980) · Journal of Infectious Diseases · doi:10.1093/infdis/142.2.229 · Cited by 98
“Recently, other endogenous opiate substances have been found in extracts of pituitary glands [7], sympathetic ganglia [8], and the adrenal medulla [8, 9].”
Background
Biomarker discovery and clinical proteomics
Silberring, J., & Ciborowski, P. S. (2009) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2009.11.007 · Cited by 101
Characteristics of electroacupuncture-induced analgesia in mice: variation with strain, frequency, intensity and opioid involvement
Huang, C., Wang, Y., Han, J., & Wan, Y. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02503-9 · Cited by 99
Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery
Gardell, L. R., King, T. E., Ossipov, M. H., Rice, K. C., Lai, J. Y., Vanderah, T. W., & Porreca, F. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.009 · Cited by 99
Dmt and opioid peptides: A potent alliance
Bryant, S. D., Jinsmaa, Y., Salvadori, S., Okada, Y., & Lazarus, L. H. (2003) · Biopolymers · doi:10.1002/bip.10399 · Cited by 99
Peripheral opioid receptor agonists for analgesia: A comprehensive review
Vadivelu, N., Mitra, S., & Hines, R. L. (2011) · Journal of Opioid Management · doi:10.5055/jom.2011.0049 · Cited by 96
Immunoreactive dynorphin in rat tissues and plasma
Spampinato, S. M., & D, A. G. M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90016-1 · Cited by 96
Brain substrates activated by electroacupuncture of different frequencies (I): comparative study on the expression of oncogene c-fos and genes coding for three opioid peptides
Guo, H.-F., Tian, J., Wang, X., Fang, Y., Hou, Y., & Han, J. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00170-2 · Cited by 95
Regulation of hypothalamic magnocellular neuropeptides and their mRNAs in the Brattleboro rat: coordinate responses to further osmotic challenge
Sherman, T., Day, R. W., Civelli, O., DOUGLASS, J. O., Herbert, E., Akil, H., & Watson, S. J. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-10-03785.1988 · Cited by 95
“Opioid peptides derived from pro-dynorphin display a marked preference for the K opioid receptor subtype (Goldstein et al., 1979), the only opioid receptor subtype found in the rat posterior pituitary (Herkenham et al., 1986; Mansour et al., 1986).”
Background
Characterization and localization of immunoreactive dynorphin, α-neo-endorphin, met-enkephalin and substance P in human spinal cord
Przewłocki, R., Gramsch, C., Pasi, A., & Herz, A. (1983) · Brain Research · doi:10.1016/0006-8993(83)91177-0 · Cited by 95
Dynorphin–Still an Extraordinarily Potent Opioid Peptide
Chavkin, C. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.083337 · Cited by 99
“As described in the initial article on dynorphin (Goldstein et al., 1979), dynorphin-A(1-13) had both high potency and low sensitivity to naloxone.”
BackgroundMethod
Pathobiology of dynorphins in trauma and disease
Hauser, K. F. (2005) · Frontiers in bioscience · doi:10.2741/1522 · Cited by 94
“Cohen: Elevated CSF Dynorphin A [1-8] in Tourette's Syndrome.”
Background
The Molecular Basis of Opioid Receptor Function
Simonds, W. F. (1988) · Endocrine Reviews · doi:10.1210/edrv-9-2-200 · Cited by 94
Opioid neurons and pain modulation: An ultrastructural analysis of enkephalin in cat superficial dorsal horn
Glazer, E. J., & Basbaum, A. I. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90139-2 · Cited by 94
O(N) Krylov-subspace method for large-scaleab initioelectronic structure calculations
Ozaki, T. (2006) · Physical Review B · doi:10.1103/physrevb.74.245101 · Cited by 93
Optimal stimulation frequency of transcutaneous electrical nerve stimulation on people with knee osteoarthritis
Law, P., & Cheing, G. L. Y. (2004) · Journal of Rehabilitation Medicine · doi:10.1080/16501970410029834 · Cited by 93
“Supposedly, 100 Hz TENS increases the release of dynorphin (an extraordinarily potent opioid peptide) (23); whereas low-frequency TENS increases the release of enkephalin and endorphin (11, 15) (a long-lasting analgesic effect) (19, 20).”
Background
Circulating opioids: Possible physiological roles in central nervous function
Henry, J. L. (1982) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(82)90040-9 · Cited by 92
Dynorphin-immunoreactive neurons in the autonomic nervous system
Vincent, S. R., Dalsgaard, C. ‐., Schultzberg, M., Hökfelt, T. G. M., Christensson, I., & Terenius, L. Y. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90208-2 · Cited by 92
Dynorphin A1–13 Causes Elevation of Serum Levels of Prolactin Through an Opioid Receptor Mechanism in Humans: Gender Differences and Implications for Modulation of Dopaminergic Tone in the Treatment of Addictions
Kreek, M. J., Schluger, J. H., Borg, L., Gunduz, M., & Ho, A. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37950-9 · Cited by 91
“…processing of dynorphin A1–13, the natural, shortened sequence of dynorphin A1–17, which has been used widely in neurobiological studies, especially because it was the initial peptide fully sequenced after the discovery by Goldstein and colleagues (Goldstein et al., 1979; Chavkin et al., 1982).”
Pro-dynorphin peptides are found in the same neurons throughout rat brain: immunocytochemical study.
Watson, S. J., Khachaturian, H., Taylor, L. P., Fischli, W., D, A. G. M., & Akil, H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.3.891 · Cited by 90
Specific opiate receptors on isolated mammalian gastric smooth muscle cells
Bitar, K. N., & Makhlouf, G. M. (1982) · Nature · doi:10.1038/297072a0 · Cited by 88
Characterization of dynorphin A-induced antinociception at spinal level
Spampinato, S. M., & Candeletti, S. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90024-x · Cited by 87
A Personal Journey of Discovery: Developing Technology and Changing Biology
Hood, L. (2008) · Annual Review of Analytical Chemistry · doi:10.1146/annurev.anchem.1.031207.113113 · Cited by 86
Self-citation
Immunoreactive dynorphin in human brain and pituitary
Gramsch, C., Höllt, V., Pasi, A., Mehraein, P., & Herz, A. (1982) · Brain Research · doi:10.1016/0006-8993(82)90930-1 · Cited by 86
O-sulphated Leu-enkephalin in brain
Unsworth, C. D., Hughes, J. M., & Morley, J. S. (1982) · Nature · doi:10.1038/295519a0 · Cited by 86
k Opioids as potential treatments for stimulant dependence
Prisinzano, T. E., Tidgewell, K. J., & Harding, W. W. (2005) · The AAPS Journal · doi:10.1208/aapsj070361 · Cited by 79
DYNORPHIN AND EPILEPSY
Simonato, M., & Romualdi, P. (1996) · Progress in Neurobiology · doi:10.1016/s0301-0082(96)00045-7 · Cited by 83
Drug dependence and the endogenous opioid system
Gerrits, M. A. F. M., Lesscher, H. B. M., & van Ree, J. M. (2003) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2003.08.003 · Cited by 82
Opioid receptor expression in the rat gastrointestinal tract: a quantitative study with comparison to the brain
Fickel, J., Bagnol, D., Watson, S. J., & Akil, H. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00266-5 · Cited by 82
Attenuation of mechanical but not thermal hyperalgesia by electroacupuncture with the involvement of opioids in rat model of chronic inflammatory pain
Huang, C., Hu, Z., Long, H., Shi, Y.-S., Han, J., & Wan, Y. (2004) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.01.006 · Cited by 80
Dynorphin A as a Potential Endogenous Ligand for Four Members of the Opioid Receptor Gene Family
Zhang, S., Tong, Y., Tian, M., DeHaven, R. N., Cortes-Burgos, L. A., Mansson, E., Simonin, F., Kieffer, B. L., & Yu, L. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37567-6 · Cited by 80
“Dynorphin A is an endogenous heptadecapeptide first isolated from pituitary glands by Goldstein and colleagues (Goldstein et al., 1979).”
Background
Glycosylated neuropeptides: A new vista for neuropsychopharmacology?
Polt, R. L., Dhanasekaran, M., & Keyari, C. M. (2005) · Medicinal Research Reviews · doi:10.1002/med.20039 · Cited by 78
“in 1979.(30) More recently a family of opioid peptides lacking the prominent YGGF ‘‘message segment’’ common to the mammalian opioid peptides was shown to be present in the skin of certain frogs.”
Background
Influence of morphine on the distal oesophagus and the lower oesophageal sphincter--a manometric study.
Dowlatshahi, K., Evander, A., Walther, B., & Skinner, D. B. (1985) · Gut · doi:10.1136/gut.26.8.802 · Cited by 77
Opioid modulation of magnocellular neurosecretory cell activity
Brown, C. H., Russell, J. A., & Leng, G. (2000) · Neuroscience Research · doi:10.1016/s0168-0102(99)00121-2 · Cited by 79
“, 1979) and the dynorphins (A1–8,1–17) (Goldstein et al., 1979; Tachibana et al., 1982) which are derived from pro-dynorphin (pro-enkephalin B) (Kakidani et al.”
Background
The Many Possible Roles of Opioids and Related Peptides in Stress‐Induced Analgesiaa
Akil, H., Young, E. A., Walker, J. M., & Watson, S. J. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb14625.x · Cited by 77
Enkephalin immunoreactivity in Golgi cells and mossy fibres of mammalian, avian, amphibian and teleost cerebellum
Schulman, J. A., Finger, T. E., Brecha, N. C., & Karten, H. J. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90026-9 · Cited by 77
Practical Aspects of in Vivo Detection of Neuropeptides by Microdialysis Coupled Off-Line to Capillary LC with Multistage MS
Li, Q., Zubieta, J.-K., & Kennedy, R. T. (2009) · Analytical Chemistry · doi:10.1021/ac802391b · Cited by 80
Relative contents and concomitant release of prodynorphin/neoendorphin-derived peptides in rat hippocampus.
Chavkin, C., Bakhit, C., Weber, E., & Bloom, F. E. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.24.7669 · Cited by 76
Behavioral effects of dynorphin1–13 in the mouse and rat: Initial observations
Walker, J. M., Katz, R. J., & Akil, H. (1980) · Peptides · doi:10.1016/0196-9781(80)90012-1 · Cited by 75
The influence of opioid receptor subtypes on the processing of nociceptive inputs in the spinal dorsal horn of the cat
Fleetwood-Walker, S. M., Hope, P. J., Mitchell, R., El-Yassir, N., & Molony, V. (1988) · Brain Research · doi:10.1016/0006-8993(88)90766-4 · Cited by 75
Distribution of enkephalin-like immunoreactivity in the rat main olfactory bulb
Bogan, N., Brecha, N. C., Gall, C. M., & Karten, H. J. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90050-1 · Cited by 74
Suppression of morphine withdrawal by electroacupuncture in rats: dynorphin and κ-opioid receptor implicated
Wu, L.-Z., Cui, C., Tian, J., Ji, D., & Han, J.-S. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02069-7 · Cited by 73
Genetics of alcoholism: Role of the endogenous opioid system
Gianoulakis, C., & de Waele, J. (1994) · Metabolic Brain Disease · doi:10.1007/bf01999765 · Cited by 70
“Indeed, twin studies, adoption and cross-fostering studies, as well as detailed pedigree analyses all suggest that alcoholism "runs" in families, while at the same time indicate that there are multiple genes which interact with environmental factors in a complex manner to increase or decrease an individual's vulnerabi…”
The central representation of an aversive event maintains the opioid and nonopioid forms of analgesia.
Grau, J. W. (1987) · Behavioral Neuroscience · doi:10.1037//0735-7044.101.2.272 · Cited by 73
Ontogeny of the leucine‐enkephalin neuron system of the rat: Immunohistochemical analysis. I. Lower brainstem
Senba, E., Shiosaka, S., Hara, Y., Inagaki, S., Kawai, Y., Takatsuki, K., Sakanaka, M., Iida, H., Takagi, H., Minagawa, H., et al. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902050404 · Cited by 72
Opioidergic regulation of astroglial/neuronal proliferation: where are we now?
Sargeant, T. J., Miller, J. H., & Day, D. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05671.x · Cited by 69
“1997), and dynorphin (Goldstein et al. 1979), which have preferential affinities for MOR/DOR, MOR, and KOR, respectively (Raynor et al.”
Background
Peptide and protein drugs: The study of their metabolism and catabolism by mass spectrometry
Κάτσιλα, Θ., Siskos, A., & Tamvakopoulos, C. (2011) · Mass Spectrometry Reviews · doi:10.1002/mas.20340 · Cited by 71
Opioid receptor gene expression in the rat brain during ontogeny, with special reference to the mesostriatal system: an in situ hybridization study
Georges, F. E., Normand, E., Bloch, B., & Moine, C. L. (1998) · Developmental Brain Research · doi:10.1016/s0165-3806(98)00082-0 · Cited by 71
Modulation of 5‐hydroxytryptamine efflux from rat cortical synaptosomes by opioids and nociceptin
Sbrenna, S., Marti, M., Morari, M., Calò, G., Guerrini, R., Beani, L., & Bianchi, C. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703321 · Cited by 71
“…peptides that act at these receptors have been identi®ed, namely the enkephalins, endorphins, dynorphins (Bradbury et al., 1976; Hughes et al., 1975; Goldstein et al., 1979) and, more recently, endomorphins (Zadina et al., 1997) and nociceptin/orphanin FQ (NC; Meunier et al., 1995; Reinscheid et…”
Background
Oxytocin in the periaqueductal gray participates in pain modulation in the rat by influencing endogenous opiate peptides
Yang, J., Liang, J., Li, P., Pan, Y.-J., Qiu, P.-Y., Zhang, J., Hao, F., & Wang, D. (2011) · Peptides · doi:10.1016/j.peptides.2011.03.007 · Cited by 69
A Study of peptide-peptide interaction by matrix-assisted laser desorption/ionization
Woods, A. S., & Huestis, M. A. (2001) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(00)00197-5 · Cited by 69
Regional Distribution of Methionine‐Enkephalin‐Arg6‐Phe7 in the Rat Brain: Comparative Study with the Distribution of Other Opioid Peptides
Giraud, P., Castanas, E., Patey, G., Oliver, C., & Rossier, J. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb11827.x · Cited by 69
“Each newly discovered peptide contains the amino acid sequence of either methionine-enkephalin (M-Enk) or leucine-enkephalin (L-Enk) (Li et al., 1977; Goldstein et al., 1979; Stern et al., 1979; Kangawa et al., 1981; Kilpatrick et al., 1981; Tachibana et al., 1982).”
Background
A subclassification of κ-sites in human brain by use of dynorphin 1–17
Pfeiffer, A. F. H., Pasi, A., Mehraein, P., & Herz, A. (1981) · Neuropeptides · doi:10.1016/0143-4179(81)90057-3 · Cited by 69
Dynorphin: friend or foe?
Caudle, R. M., & Mannes, A. J. (2000) · Pain · doi:10.1016/s0304-3959(00)00360-2 · Cited by 66
“…of Anesthesia, University of Pennsylvania, Philadelphia, PA 19104, USA Received 22 May 2000; accepted 20 June 2000 The powerful endogenous morphine, as the name `dynorphin' signi®es, was isolated approximately a quarter century ago by Avram Goldstein's group at Stanford (Goldstein et al., 1979).”
Background
Primary structure and functional expression of a guinea pig kappa opioid (dynorphin) receptor.
Xie, G. X., Meng, F., Mansour, A., Thompson, R. C., Hoversten, M. T., D, A. G. M., Watson, S. J., & Akil, H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3779 · Cited by 66
The effects of stress on central nervous system concentrations of the opioid peptide, dynorphin
Morley, J. E., Elson, M. K., Levine, A. S., & Shafer, R. B. (1982) · Peptides · doi:10.1016/0196-9781(82)90058-4 · Cited by 66
The Role of Neurokinin B Signalling in Reproductive Neuroendocrinology
Grachev, P., Millar, R. P., & O'Byrne, K. T. (2013) · Neuroendocrinology · doi:10.1159/000357734 · Cited by 65
Opioids Resistance in Chronic Pain Management
Morrone, L. A., Scuteri, D., Rombolà, L., Mizoguchi, H., & Bagetta, G. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666161101092822 · Cited by 67
Dynorphin A (1–13) Neurotoxicity in Vitro: Opioid and Non-Opioid Mechanisms in Mouse Spinal Cord Neurons
Hauser, K. F., Foldes, J. K., & Turbek, C. S. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7235 · Cited by 65
“Intrathecal administration of low dosages of dynorphin A (1-13) (19,29) causes opioid analgesia in tail-flick and hot-plate assays that can be prevented by opioid antagonists (45).”
Background
Endogenous morphine and its metabolites in mammals: History, synthesis, localization and perspectives
Laux‐Biehlmann, A., Mouheiche, J., Vérièpe, J., & Goumon, Y. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.013 · Cited by 62
“…b-endorphin (Bradbury et al., 1976; Graf et al., 1976; Lazarus et al., 1976; Li and Chung, 1976; Li et al., 1976), dynorphin (Cox et al., 1975; Goldstein et al., 1979; Lowney et al., 1979), nociceptin/orphanin FQ (Meunier et al., 1995; Reinscheid et al., 1995) and endomorphins (Hackler et…”
Spinal opioid systems in inflammation
Stanfa, L. C., & Dickenson, A. H. (1995) · Inflammation Research · doi:10.1007/bf01782974 · Cited by 64
“Since the discovery of the endogenous opioid peptides twenty years ago [1, 2], attempts have been made to determine the role played by these endogenous opioid systems in the control of pain mechanisms, particularly in protracted pain states.”
Psychobiology of Opioids
Oliverio, A., Castellano, C., & Puglisi‐Allegra, S. (1984) · International review of neurobiology · doi:10.1016/s0074-7742(08)60682-0 · Cited by 64
Dynorphins: Similar relative potencies on μ-, δ- and κ-opiate receptors
Quirion, R., & Pert, C. B. (1981) · European Journal of Pharmacology · doi:10.1016/0014-2999(81)90125-4 · Cited by 62
Intrathecal dynorphin A1–13 and dynorphin A3–13 reduce rat spinal cord blood flow by non-opioid mechanisms
Long, J. B., Kinney, R. C., Malcolm, D., Graeber, G. M., & Holaday, J. W. (1987) · Brain Research · doi:10.1016/0006-8993(87)91683-0 · Cited by 62
Strategies for Developing κ Opioid Receptor Agonists for the Treatment of Pain with Fewer Side Effects
Paton, K. F., Atigari, D. V., Kaska, S., Prisinzano, T. E., & Kivell, B. M. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.000134 · Cited by 61
“The endogenous agonists for the KOPr are the dynorphin class of opioid peptides (Goldstein et al., 1979; Chavkin et al., 1982).”
Background
The β-Endorphin Role in Stress-Related Psychiatric Disorders
Wagner, A. M., Dikshtein, Y., & Yadid, G. (2009) · Current Drug Targets · doi:10.2174/138945009789735147 · Cited by 59
“Later, researchers succeeded in isolating and characterizing the enkephalins [2], dynorphins [3, 4] and also endorphin [5].”
From Pleasure to Pain, and Back Again: The Intricate Relationship Between Alcohol and Nociception
Robins, M. T., Heinricher, M. M., & Ryabinin, A. E. (2019) · Alcohol and Alcoholism · doi:10.1093/alcalc/agz067 · Cited by 63
“Increases in the endogenous KOR agonist dynorphin lead to decreased dopamine release in regions such as the NAC, resulting in dysphoria and stress (Goldstein et al., 1979; Anderson and Becker, 2017).”
Background
Dynorphin‐(1–13).
Turcotte, A., Lalonde, J.-M., St-Pierre, S. A., & Lemaire, S. (1984) · International journal of peptide & protein research · doi:10.1111/j.1399-3011.1984.tb02732.x · Cited by 60
Ultrastructural analysis of dynorphin B–immunoreactive cells and terminals in the superficial dorsal horn of the deafferented spinal cord of the rat
Cho, H. J., & Basbaum, A. I. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902810204 · Cited by 61
Different opioid systems may participate in post-electro-convulsive shock (ECS) analgesia and catalepsy
Urca, G., Yitzhaky, J., & Frenk, H. (1981) · Brain Research · doi:10.1016/0006-8993(81)90301-2 · Cited by 60
Dynorphin A1–17-Induced Feeding: Pharmacological Characterization Using Selective Opioid Antagonists and Antisense Probes in Rats
Silva, R. M., Grossman, H. C., Hadjimarkou, M. M., Rossi, G. C., Pasternak, G. W., & Bodnar, R. J. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.2.513 · Cited by 58
The μ-opioid receptor gene-dose dependent reductions in G-protein activation in the pons/medulla and antinociception induced by endomorphins in μ-opioid receptor knockout mice
Mizoguchi, H., Narita, M., Oji, D. E., Suganuma, C., Nagase, H., Sora, I., Uhl, G. R., Cheng, E. Y., & Tseng, L. F. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00298-5 · Cited by 58
New δ-opioid antagonists as pharmacological probes
Bryant, S. D., Salvadori, S., Cooper, P. S., & Lazarus, L. H. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01156-5 · Cited by 58
Release of immunoreactive-dynorphin from the isolated guinea-pig small intestine is reduced during peristaltic activity
Krömer, W., Höllt, V., Schmidt, H. H. H. W., & Herz, A. (1981) · Neuroscience Letters · doi:10.1016/0304-3940(81)90100-2 · Cited by 58
Behavioral effects of dynorphin — a novel opioid neuropeptide
Katz, R. J. (1980) · Neuropharmacology · doi:10.1016/0028-3908(80)90074-x · Cited by 58

Authors: Goldstein, A., Tachibana, S., Lowney, L. I., Hunkapiller, M., & Hood, L.
Affiliations: California Institute of Technology (US)
ORCID: Hunkapiller, M
Hood, L
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1979-12
Volume: 76
Issue: 12
Pages: 6666-6670
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.76.12.6666
PMC: PMC411929
OpenAlex: W2033680879
Cited by: 882
References: 18
Citations by year: 2026: 8 · 2025: 9 · 2024: 8 · 2023: 14 · 2022: 10 · 2021: 14 · 2020: 23 · 2019: 13 · 2018: 8 · 2017: 9 · 2016: 6 · 2015: 8 · 2014: 16 · 2013: 23 · 2012: 18
FWCI: 24.93
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
Keywords: dynorphin A(1-13), opioid peptides, leu-enkephalin, enkephalin, naloxone, opioid receptors, vas deferens, peptide degradation, immunoreactivity
MeSH terms: Amino Acid Sequence, Animals, Biological Assay, Dose-Response Relationship, Drug, Endorphins, Guinea Pigs, Ileum, Radioligand Assay, Receptors, Opioid, Structure-Activity Relationship, Swine, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dynorphin-(1-13), an extraordinarily potent opioid peptide.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks