Cited by 82Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on BehaviorOpioid Use Disorder Treatment

Drug dependence and the endogenous opioid system

Gerrits, Mirjam A.F.M, Lesscher, Heidi B.M, van Ree, Jan M·2003·European Neuropsychopharmacology

Abstract

The discovery of endogenous opioids has markedly influenced the research on the biology of drug dependence. Evidence has been presented that these brain substances are self-administered by laboratory animals. This finding, among others, has led to the hypothesis that endogenous opioids are involved in reinforcing habits, including dependence on drugs of abuse. The course of drug dependence is presented as a continuum from no drug use via controlled use to an actual dependence on the drug. Specific brain opioid systems belonging to four conceptualized brain circuits are described to be involved during the different phases of the drug dependence continuum. More recent research to delineate the role of endogenous opioid systems in drug dependence has focussed on genetic research in humans and animals. Among others, the findings obtained from studies of opioid receptor and opioid peptide precursor knockout mice provided further support for a role of endogenous opioid systems in drug dependence, in agreement with previous pharmacological studies.

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Crossref · 10.1016/j.euroneuro.2003.08.003

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Authors
Gerrits, M. A. F. M., Lesscher, H. B. M., & van Ree, J. M.
Affiliations
Utrecht University (NL)
Corresponding author
Gerrits, Mirjam A.F.M
Venue
European Neuropsychopharmacology
Publisher
Elsevier BV
Published
2003-12
Volume
13
Issue
6
Pages
424-434
ISSN
0924-977X (ISSN-L)
OpenAlex
W2159328887
Cited by
82
References
93
Citations by year
2026: 3 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2015: 4 · 2014: 2 · 2013: 6 · 2012: 2
FWCI
0.76
Type
journal article
Language
en
Open access
closed
Locations
  • European Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords
drug addiction, endogenous opioids, opioid system, self-administration, reinforcement, drug abuse, brain circuits, opioid receptors, knockout mice, genetic research
MeSH terms
Animals, Humans, Narcotics, Neural Pathways, Receptors, Opioid, Mice, Knockout, Substance-Related Disorders, Mice, Rats

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