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Structure of poly(adenosine diphosphate ribose): identification of 2'-[1''-ribosyl-2''-(or 3''-)(1'''-ribosyl)]adenosine-5',5'',5'''-tris(phosphate) as a branch linkage.
Open accessAbstract
Poly([14C]adenosine diphosphate ribose) was synthesized from [14C]NAD+ with calf thymus nuclei. The fraction containing poly(adenosine diphosphate ribose) eluted with 0.22--0.40 M phosphate buffer (pH 6.8) from a hydroxylapatite column, was completely hydrolyzed with venom phosphodiesterase, and was separated by DEAE-Sephadex A-25 column chromatography in 7 M urea. A new compound, which constituted 2% of the products from poly(adenosine diphosphate ribose), was found in addition to the expected products--i.e., 5'-AMP, 2'-(1''-ribosyl)adenosine-5',5''-bis(phosphate), and its derivatives. This compound was identified as 2'-[1''-ribosyl 2''-(or 3''-)(1'''-ribosyl)]adenosine-5',5'',5'''-tris(phosphate). The existence of this compound is evidence of a branching structure of poly(adenosine diphosphate ribose), which was previously thought to be a linear molecule. The content of this compound suggests that the frequency of branching is about 1 per 20--30 adenosine diphosphate ribose residues of high molecular weight poly(adenosine diphosphate ribose).
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Cited by
Hassa, P. (2008) · Frontiers in Bioscience · doi:10.2741/2909 · Cited by 584
Molecular and biochemical features of poly (ADP-ribose) metabolism
Lautier, D., Lagueux, J., Thibodeau, J., M�nard, L., & Poirier, G. G. (1993) · Molecular and Cellular Biochemistry · doi:10.1007/bf01076101 · Cited by 301
PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification
Langelier, M.-F., Eisemann, T., Riccio, A. A., & Pascal, J. M. (2018) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2018.11.002 · Cited by 196
Metadata
- Authors
- Miwa, M., Saikawa, N., Yamaizumi, Z., Nishimura, S., & Sugimura, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1979-02
- Volume
- 76
- Issue
- 2
- Pages
- 595-599
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2100395704
- Cited by
- 158
- References
- 0
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Structure of poly(adenosine diphosphate ribose): identification of 2'-[1''-ribosyl-2''-(or 3''-)(1'''-ribosyl)]adenosine-5',5'',5'''-tris(phosphate) as a branch linkage. https://app.cochat.ai/papers/10.1073/pnas.76.2.595
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- Miwa, M., Saikawa, N., Yamaizumi, Z., Nishimura, S., & Sugimura, T. (1979). Structure of poly(adenosine diphosphate ribose): identification of 2'-[1''-ribosyl-2''-(or 3''-)(1'''-ribosyl)]adenosine-5',5'',5'''-tris(phosphate) as a branch linkage. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.76.2.595
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
