PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification
Open accessAbstract
Poly(ADP-ribose) is a posttranslational modification and signaling molecule that regulates many aspects of human cell biology, and it is synthesized by enzymes known as poly(ADP-ribose) polymerases, or PARPs. A diverse collection of domain structures dictates the different cellular roles of PARP enzymes and regulates the production of poly(ADP-ribose). Here we primarily review recent structural insights into the regulation and catalysis of two family members: PARP-1 and Tankyrase. PARP-1 has multiple roles in the cellular response to DNA damage and the regulation of gene transcription, and Tankyrase regulates a diverse set of target proteins involved in cellular processes such as mitosis, genome integrity, and cell signaling. Both enzymes offer interesting modes of regulating the production and the target site selectivity of the poly(ADP-ribose) modification.
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- Authors
- Langelier, M.-F., Eisemann, T., Riccio, A. A., & Pascal, J. M.
- Affiliations
- Université de Montréal (CA)
- Corresponding author
- Pascal, John M
- Venue
- Current Opinion in Structural Biology
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 53
- Pages
- 187-198
- ISSN
- 0959-440X (ISSN-L)
- PMC
- PMC6687463
- OpenAlex
- W2901569771
- Cited by
- 196
- References
- 76
- Citations by year
- 2026: 17 · 2025: 23 · 2024: 25 · 2023: 30 · 2022: 28 · 2021: 27 · 2020: 29 · 2019: 16 · 2018: 1
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Structural Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Canadian Institute of Health Research (BMA342854, PJT374609)
- National Cancer Institute grant Structural Biology of DNA Repair (CA92584)
- Topics
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- PARP1, tankyrase, poly(ADP-ribose), poly(ADP-ribose) polymerase, post-translational modification, enzyme catalysis, enzyme regulation, DNA damage response, transcriptional regulation, mitosis, genome stability, signal transduction, protein domain structure
- MeSH terms
- Poly (ADP-Ribose) Polymerase-1, Protein Domains, DNA-Binding Proteins, Humans, Tankyrases
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