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DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.
Open accessAbstract
In this report, we demonstrate the feasibility of transforming mouse cells deficient in adenine phosphoribosyltransferase (aprt; AMP:pyrophosphate phosphoribosyltransferase, EC 2.4.2.7) to the aprt+ phenotype by means of DNA-mediated gene transfer. Transformation was effected by using unfractionated high molecular weight genomic DNA from Chinese hamster, human, and mouse cells and restriction endonuclease-digested DNA from rabbit liver. The transformation frequency observed was between 1 and 10 colonies per 10(6) cells per 20 microgram of donor DNA. Transformants displayed enzymatic activity that was donor derived as demonstrated by isoelectric focusing of cytoplasmic extracts. These transformants fall into two classes: those that are phenotypically stable when grown in the absence of selective pressure and those that are phenotypically unstable under the same conditions.
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Cited by
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Kohl, N. E., Emini, E. A., Schleif, W. A., Davis, L. J., Heimbach, J. C., Dixon, R. A., Scolnick, E. M., & Sigal, I. S. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.13.4686 · Cited by 1,307
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Metadata
- Authors
- Wigler, M., Pellicer, A., Silverstein, S., Axel, R., Urlaub, G., & Chasin, L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1979-03
- Volume
- 76
- Issue
- 3
- Pages
- 1373-1376
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2084099638
- Cited by
- 1,279
- References
- 0
- FWCI
- 18.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Wigler, M., Pellicer, A., Silverstein, S., Axel, R., Urlaub, G., & Chasin, L. (1979). DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.76.3.1373
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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