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Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.
Open accessAbstract
Fusion of P3 X 63 Ag8 mouse myeloma cells with splenocytes obtained from mice immunized with cells derived from human colorectal carcinomas resulted in the production of antibody-secreting hybridomas. Two hybridomas (1083-17 and 1116-56) and their clones secreted antibodies binding specifically to human colorectal carcinoma cells either grown in culture or obtained from patients, but did not bind to normal colonic mucosa or other normal and malignant human cells. The binding specificity was consistent in three assays: radioimmunoassay, mixed hemadsorption, and immunofluorescence. Adsorption of these antibodies to colorectal carcinoma cell lines totally eliminated their specific binding.
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Cited by
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Yamashita, T., Forgues, M., Wang, W., Kim, J. W., Ye, Q., Jia, H., Budhu, A., Zanetti, K. A., Chen, Y., Qin, L.-X., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6013 · Cited by 717
EpCAM (CD326) finding its role in cancer
Baeuerle, P. A., & Gires, O. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603494 · Cited by 527
Activation of Hepatic Stem Cell Marker EpCAM by Wnt–β-Catenin Signaling in Hepatocellular Carcinoma
Yamashita, T., Budhu, A., Forgues, M., & Wang, X. W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0908 · Cited by 446
Zhang, B.-L., Li, D., Gong, Y.-L., Huang, Y., Qin, D.-Y., Jiang, L., Liang, X., Yang, X., Gou, H.-F., Wang, Y.-S., et al. (2019) · Human Gene Therapy · doi:10.1089/hum.2018.229 · Cited by 88
Alkhader, E., Roberts, C. J., Rosli, R., Yuen, K. H., Seow, E. K., Lee, Y. Z., & Billa, N. (2018) · Journal of Biomaterials Science, Polymer Edition · doi:10.1080/09205063.2018.1541500 · Cited by 53
Metadata
- Authors
- Herlyn, M., Steplewski, Z., Herlyn, D., & Koprowski, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1979-03
- Volume
- 76
- Issue
- 3
- Pages
- 1438-1442
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2048025181
- Cited by
- 656
- References
- 0
- FWCI
- 29.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies. https://app.cochat.ai/papers/10.1073/pnas.76.3.1438
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- Herlyn, M., Steplewski, Z., Herlyn, D., & Koprowski, H. (1979). Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.76.3.1438
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
