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Chromosomal location of the genes for human immunoglobulin heavy chains.
Open accessAbstract
We have studied somatic cell hybrids between P3x63Ag8 mouse myeloma cells deficient in hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) and either human peripheral lymphocytes or human lymphoblastoid or myeloma cells for the production of human immunoglobulin chains and for the expression of enzyme markers assigned to each of the different human chromosomes. Human chromosome 14 was the only human chromosome present in all independent hybrids producing mu, gamma, and alpha human heavy chains. In two of the independent hybrids that produced human heavy chains, human chromosome 14 was the only human chromosome present in the hybrid cells. Loss of human chromosome 14 from these hybrids resulted in the concomitant loss of their ability to produce human immunoglobulin heavy chains. In view of these results, we conclude that the genes for human immunoglobulin heavy chains are located on human chromosome 14 in immunoglobulin-producing human cells.
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Cited by
Croce, C. M. (2008) · New England Journal of Medicine · doi:10.1056/nejmra072367 · Cited by 1,055
Self-citationTsujimoto, Y., Gorham, J., Cossman, J., Jaffe, E., & Croce, C. M. (1985) · Science · doi:10.1126/science.3929382 · Cited by 991
Self-citationTranscriptional activation of the translocated c- myc oncogene in Burkitt lymphoma
Erikson, J., Ar-Rushdi, A., Drwinga, H. L., Nowell, P. C., & Croce, C. M. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.3.820 · Cited by 342
Self-citationNucleotide sequence of cloned cDNA of human c-myc oncogene
Watt, R., Stanton, L. W., Marcu, K. B., Gallo, R. C., Croce, C. M., & Rovera, G. (1983) · Nature · doi:10.1038/303725a0 · Cited by 295
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Metadata
- Authors
- Croce, C. M., Shander, M., Martinis, J., Cicurel, L., D'Ancona, G. G., Dolby, T. W., & Koprowski, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1979-07
- Volume
- 76
- Issue
- 7
- Pages
- 3416-3419
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2094239210
- Cited by
- 371
- References
- 0
- FWCI
- 31.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Croce, C. M., Shander, M., Martinis, J., Cicurel, L., D'Ancona, G. G., Dolby, T. W., & Koprowski, H. (1979). Chromosomal location of the genes for human immunoglobulin heavy chains. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.76.7.3416
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