The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining
Abstract
In this study, the joining sequences between chromosomes 14 and 18 on the 14q + chromosomes of a patient with pre-B-cell leukemia and four patients with follicular lymphoma carrying a t(14;18) chromosome translocation were analyzed. In each case, the involved segment of chromosome 18 has recombined with the immunoglobulin heavy-chain joining segment (J H ) on chromosome 14. The sites of the recombination on chromosome 14 are located close to the 5′ end of the involved J H segment, where the diversity (D) regions are rearranged with the J H segments in the production of active heavy-chain genes. As extraneous nucleotides (N regions) were observed at joining sites and specific signal-like sequences were detected on chromosome 18 in close proximity to the breakpoints, it is concluded that the t(14;18) chromosome translocation is the result of a mistake during the process of VDJ joining at the pre-B-cell stage of differentiation. The putative recombinase joins separated DNA segments on two different chromosomes instead of joining separated segments on the same chromosome, causing a t(14;18) chromosome translocation in the involved B cells.
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Cites
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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
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Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
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Metadata
- Authors
- Tsujimoto, Y., Gorham, J., Cossman, J., Jaffe, E., & Croce, C. M.
- Venue
- Science
- Published
- 1985-09-27
- Volume
- 229
- Issue
- 4720
- Pages
- 1390-1393
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1967354499
- Cited by
- 991
- References
- 23
- FWCI
- 23.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining. https://app.cochat.ai/papers/10.1126/science.3929382
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- Tsujimoto, Y., Gorham, J., Cossman, J., Jaffe, E., & Croce, C. M. (1985). The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining. Science. https://doi.org/10.1126/science.3929382
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