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Platelet-derived growth factor: purification and partial characterization.
Open accessAbstract
A cationic protein that stimulates DNA synthesis in human cultured cells was isolated from human platelets by ion exchange chromatography, hydrophobic chromatography, gel chromatography, and gel electrophoresis in sodium dodecyl sulfate. The electrophoretic behavior of biologically active or radioiodinated and reduced growth factor indicated that the native protein (approximately 30,000 daltons) was composed of two different polypeptides (approximately 13,000-14,000 and 16,000-17,000 daltons, respectively) linked via reduction-susceptible bonds. The stimulatory activity on human glial cells of the purified product at a concentration of approximately 4 ng/ml (0.13 nM) was equal to that of 1% human serum.
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Citations
Cited by
The Pathogenesis of Atherosclerosis — An Update
Ross, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198602203140806 · Cited by 4,877
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
Greenberg, M. E., & Ziff, E. B. (1984) · Nature · doi:10.1038/311433a0 · Cited by 3,064
Waterfield, M. D., Scrace, G. T., Whittle, N., Stroobant, P., Johnsson, A., Wasteson, Å., Westermark, B., Heldin, C.-H., Huang, J. S., & Deuel, T. F. (1983) · Nature · doi:10.1038/304035a0 · Cited by 1,616
Self-citationDoolittle, R. F., Hunkapiller, M. W., Hood, L. E., Devare, S. G., Robbins, K. C., Aaronson, S. A., & Antoniades, H. N. (1983) · Science · doi:10.1126/science.6304883 · Cited by 1,536
PLATELET-DERIVED GROWTH FACTOR
Ross, R. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92760-8 · Cited by 940
Metadata
- Authors
- Heldin, C. H., Westermark, B., & Wasteson, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1979-08
- Volume
- 76
- Issue
- 8
- Pages
- 3722-3726
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2081203911
- Cited by
- 429
- References
- 0
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Heldin, C. H., Westermark, B., & Wasteson, A. (1979). Platelet-derived growth factor: purification and partial characterization. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.76.8.3722
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