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Enhanced nonenzymatic glucosylation of human serum albumin in diabetes mellitus.
Open accessAbstract
Use of an ion exchange chromatographic method and a colorimetric method with thiobarbituric acid showed that levels of nonenzymatically glucosylated serum albumin were increased in patients with poorly controlled diabetes mellitus compared to controls. The two methods correlated well (r = 0.99) and clearly discriminated between normal and poorly controlled diabetic populations. The levels of glycosylated hemoglobin were also measured in both populations. Several patients apparently in good control based on glycosylated hemoglobin measurements were found to have increased levels of glycosylated albumin. Because albumin has a shorter circulating half-life than does the human erythrocyte, the plasma concentration of glucosylated albumin should be expected to reflect short-term control of hyperglycemia in diabetes. The studies reported here suggest that the level of glucosylated albumin may indeed be a sensitive indicator of moderate hyperglycemia and of early glucose intolerance.
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Cited by
Carter, D. C., & Ho, J. X. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60640-3 · Cited by 3,187
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Armbruster, D. A. (1987) · Clinical Chemistry · doi:10.1093/clinchem/33.12.2153 · Cited by 437
The glycation of albumin: Structural and functional impacts
Rondeau, P., & Bourdon, E. (2011) · Biochimie · doi:10.1016/j.biochi.2010.12.003 · Cited by 433
Clinical impact of glycated albumin as another glycemic control marker
Koga, M., & Kasayama, S. (2010) · Endocrine Journal · doi:10.1507/endocrj.k10e-138 · Cited by 290
Hypothesis: Glucose as a Mediator of Aging
Cerami, A. (1985) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1985.tb06319.x · Cited by 275
Metadata
- Authors
- Guthrow, C. E., Morris, M. A., Day, J. F., Thorpe, S. R., & Baynes, J. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1979-09
- Volume
- 76
- Issue
- 9
- Pages
- 4258-4261
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2137239999
- Cited by
- 266
- References
- 0
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Enhanced nonenzymatic glucosylation of human serum albumin in diabetes mellitus. https://app.cochat.ai/papers/10.1073/pnas.76.9.4258
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- Guthrow, C. E., Morris, M. A., Day, J. F., Thorpe, S. R., & Baynes, J. W. (1979). Enhanced nonenzymatic glucosylation of human serum albumin in diabetes mellitus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.76.9.4258
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
