Clinical impact of glycated albumin as another glycemic control marker
Open accessAbstract
It is known that glycation among various proteins is increased in diabetic patients compared with non-diabetic subjects. Currently, among these glycated proteins, glycated hemoglobin (HbA(1C)) is used as the gold standard index of glycemic control in clinical practice for diabetes treatment. However, HbA(1C) does not accurately reflect the actual status of glycemic control in some conditions where plasma glucose changes during short term, and in patients who have diseases such as anemia and variant hemoglobin. In comparison, another index of glycemic control, glycated albumin (GA), more accurately reflects changes in plasma glucose during short term and also postprandial plasma glucose. Although GA is not influenced by disorders of hemoglobin metabolism, it is affected by disorders of albumin metabolism. This review summarizes diseases and pathological conditions where GA measurement is useful. These include the status of glycemic control changes during short term, diseases which cause postprandial hyperglycemia, iron deficiency anemia, pregnancy, chronic liver disease (liver cirrhosis), chronic renal failure (diabetic nephropathy), and variant hemoglobin.
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Glycated albumin has been used as an indicator of glycemic control over the preceding 2 weeks.
“In addition to HbAc, glycated albumin (GA) has been used as an indicator of glycemic control () over the preceding weeks.”
From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [241]
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Glycemic Variability: How Do We Measure It and Why Is It Important?
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- Authors
- Koga, M., & Kasayama, S.
- Affiliations
- Kinki Central Hospital (JP)
- Nippon Life Hospital (JP)
- Venue
- Endocrine Journal
- Publisher
- Japan Endocrine Society
- Published
- 2010
- Volume
- 57
- Issue
- 9
- Pages
- 751-762
- ISSN
- 0918-8959 (ISSN-L)
- 1348-4540
- OpenAlex
- W2084242756
- Cited by
- 290
- References
- 69
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 12 · 2023: 17 · 2022: 15 · 2021: 18 · 2020: 26 · 2019: 10 · 2018: 22 · 2017: 17 · 2016: 16 · 2015: 14 · 2014: 31 · 2013: 26 · 2012: 30
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrine Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- glycated albumin, glycemic control, HbA1c, diabetes mellitus, albumin metabolism, postprandial hyperglycemia, iron deficiency anemia, pregnancy, chronic liver disease, liver cirrhosis, chronic kidney disease, diabetic nephropathy, hemoglobin variants, anemia
- MeSH terms
- Glycated Serum Albumin, Blood Glucose, Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Female, Glycated Hemoglobin, Hemoglobins, Abnormal, Humans, Hyperglycemia, Liver Cirrhosis, Pregnancy, Serum Albumin, Biomarkers, Glycation End Products, Advanced, Anemia, Iron-Deficiency
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