The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography.
Open accessAbstract
We have observed two discrete populations of opiate receptors that are differently localized in rat brain. Morphine-like (mu) receptors, labeled by 125I-labeled [D-Ala-2MePhe4Met(O)5-ol]enkephalin, are concentrated selectively in lamina IV of the cerebral cortex, certain thalamic nuclei, and the periaqueductal grey, while delta receptors, labeled by 125I-labeled [D-Ala2-D-Leu5]enkephalin, are more diffused, having high densities in cerebral cortex, corpus striatum, amygdala, and olfactory tubercle. Because of similarities in their localizations, we propose that mu and delta receptors are respectively the physiologic receptors for [Met]- and [Leu]enkephalin neurons. These distributions reflect the different physiological functions attributed to mu and delta receptors and thus represent discrete functions of [Met]- and [Leu]enkephalin neurons.
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Cites
Martin, W. R., Eades, C. G., Thompson, J. A., Huppler, R. E., & Gilbert, P. E. (1976) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)30536-7 · Cited by 2,992
Endogenous opioid peptides: multiple agonists and receptors
Lord, J. A. H., Waterfield, A. A., Hughes, J., & Kosterlitz, H. W. (1977) · Nature · doi:10.1038/267495a0 · Cited by 2,485
Cited by
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357
Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.
North, R. A., Williams, J. T., Surprenant, A., & Christie, M. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.15.5487 · Cited by 618
Mu Opioids and Their Receptors: Evolution of a Concept
Pasternak, G. W., & Pan, Y.-X. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007138 · Cited by 578
Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis
Chesselet, M.-F. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90058-7 · Cited by 577
Herkenham, M., & Pert, C. B. (1981) · Nature · doi:10.1038/291415a0 · Cited by 543
Metadata
- Authors
- Goodman, R. R., Snyder, S. H., Kuhar, M. J., & Young, W. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-10
- Volume
- 77
- Issue
- 10
- Pages
- 6239-6243
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1967746911
- Cited by
- 466
- References
- 2
- FWCI
- 11.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Goodman, R. R., Snyder, S. H., Kuhar, M. J., & Young, W. S. (1980). Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.10.6239
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
