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Escherichia coli mutator mutants deficient in methylation-instructed DNA mismatch correction.
Open accessAbstract
Our approach to the isolation of DNA mismatch-correction-deficient mutants was based upon the isolation of 2-aminopurine-resistant second-site revertants of Escherichia coli dam- mutants. We isolated such second-site revertants which, when separated from the dam- mutation, have a mutator character of their own. These new mutators all mapped at three known mutator loci, mutH, mutL, and mutS, which exhibit the same mutagenic spectrum as the dam- mutator: increased levels of base substitution and frameshift mutations. The mutator potencies of double and triple mut- mutants suggest that these mutators are involved in the same general mismatch-repair pathway. All these mutations result in a hyper-recombination phenotype, but in four-factor crosses among lambda phages, a specific loss of intragenic recombination (Pam3 X Pam80) was found in mutL and mutS mutants, as would be predicted from the postulated role of mismatch correction in gene conversion and high negative interference phenomena.
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Cited by
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Blount, Z. D., Barrick, J. E., Davidson, C. J., & Lenski, R. E. (2012) · Nature · doi:10.1038/nature11514 · Cited by 612
Elhai, J., Vepritskiy, A., Muro-Pastor, A. M., Flores, E., & Wolk, C. P. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.6.1998-2005.1997 · Cited by 334
Kunkel, T. A., & Alexander, P. S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42446-x · Cited by 299
Metadata
- Authors
- Glickman, B. W., & Radman, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1980-02
- Volume
- 77
- Issue
- 2
- Pages
- 1063-1067
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2005820729
- Cited by
- 395
- References
- 0
- FWCI
- 10.63
- Type
- journal article
- Language
- en
- Open access
- green
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- Glickman, B. W., & Radman, M. (1980). Escherichia coli mutator mutants deficient in methylation-instructed DNA mismatch correction. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.77.2.1063
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